Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 5/20 | 0.45 |
| ▸ | LOX | P28300 | 2/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9970103 | 0.98 | AOC3 (0.44) | AOC3LOXMCHR1TLR8LMNA | |
| SCHEMBL19969290 | 0.86 | LMNA (0.50) | AOC3LOXMCHR1TLR8LMNA | |
| SCHEMBL19969259 | 0.84 | LMNA (0.49) | AOC3LOXMCHR1TLR8LMNA | |
| SCHEMBL17119505 | 0.80 | KDM4E (0.38) | AOC3LOXLMNACYP3A4KDM4E | |
| SCHEMBL9970099 | 0.73 | AOC3 (0.44) | AOC3LOXLMNAKDM4E | |
| SCHEMBL9970100 | 0.71 | AOC3 (0.61) | AOC3LMNAMAPTCYP2C9CYP2C19 | |
| SCHEMBL9970110 | 0.71 | LMNA (0.38) | AOC3LOXLMNAKDM4E | |
| SCHEMBL14646864 | 0.69 | LMNA (0.56) | LMNACYP1A2CYP2C19KDM4E | |
| SCHEMBL2986517 | 0.69 | MCHR1 (0.41) | MCHR1TLR8LMNAMEN1NR1I2 | |
| SCHEMBL9970107 | 0.69 | AOC3 (0.39) | AOC3LOXLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8822542-B2 | Isoketal scavengers and mitigation of disorders involving oxidative injury | VANDERBILT UNIVERSITY (US) | 2014-09-02 | — | — | US | disclosed |
| US-20120157501-A1 | ISOKETAL SCAVENGERS AND MITIGATION OF DISORDERS INVOLVING OXIDATIVE INJURY | VANDERBILT UNIVERSITY | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157501-A1 | ISOKETAL SCAVENGERS AND MITIGATION OF DISORDERS INVOLVING OXIDATIVE INJURY | PDXK, KYNU, FN3K | AOC3 501/4885LOX 34/4885MCHR1 2805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.