Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15095089 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1TDP1TSHRMAPK1 | |
| SCHEMBL11659742 | 0.77 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1TDP1TSHRMAPK1 | |
| SCHEMBL812694 | 0.77 | — | — | |
| SCHEMBL647425 | 0.77 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1TDP1TSHRMAPK1 | |
| SCHEMBL10900694 | 0.76 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1TDP1TSHRMAPK1 | |
| SCHEMBL23521486 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1TDP1TSHRMAPK1 | |
| SCHEMBL3856312 | 0.74 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1TDP1TSHRMAPK1 | |
| SCHEMBL8622001 | 0.74 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1TDP1TSHRMAPK1 | |
| SCHEMBL2783666 | 0.74 | TSHR (0.46) | SMN1; SMN2ALDH1A1TDP1TSHRMAPK1 | |
| SCHEMBL752412 | 0.73 | TSHR (0.46) | SMN1; SMN2ALDH1A1TDP1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2022775-B1 | Trihydroxy polyunsaturated eicosanoids | UNIV SOUTHERN CALIFORNIA (US) | 2014-10-15 | — | — | EP | disclosed |
| US-8802874-B2 | Trihydroxy polyunsaturated eicosanoid derivatives | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2014-08-12 | — | — | US | disclosed |
| US-20130296590-A1 | TRIHYDROXY POLYUNSATURATED EICOSANOID DERIVATIVES | NATIONAL INSTITUTES OF HEALTH | 2013-11-07 | — | — | US | disclosed |
| US-8461201-B2 | Trihydroxy polyunsaturated eicosanoid derivatives | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2013-06-11 | — | — | US | disclosed |
| US-20120157700-A1 | TRIHYDROXY POLYUNSATURATED EICOSANOID DERIVATIVES | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2012-06-21 | — | — | US | disclosed |
| US-20110237545-A1 | TRIHYDROXY POLYUNSATURATED EICOSANOID DERIVATIVES | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2011-09-29 | — | — | US | disclosed |
| US-7902257-B2 | Trihydroxy polyunsaturated eicosanoid | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2011-03-08 | — | — | US | disclosed |
| US-20090291916-A1 | Trihydroxy Polyunsaturated Eicosanoid | UNIVERSITY OF SOUTHERN CALIFORNIA | 2009-11-26 | — | — | US | disclosed |
| US-7582785-B2 | Trihydroxy polyunsaturated eicosanoid derivatives | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237545-A1 | TRIHYDROXY POLYUNSATURATED EICOSANOID DERIVATIVES | ALOX5, ALOX15, ALOX15B | SMN1; SMN2 4587/4885ALDH1A1 1027/4885TDP1 3414/4885 |
| US-20130296590-A1 | TRIHYDROXY POLYUNSATURATED EICOSANOID DERIVATIVES | ALOX5, ALOX15, ALOX15B | SMN1; SMN2 4587/4885ALDH1A1 1027/4885TDP1 3414/4885 |
| US-20090291916-A1 | Trihydroxy Polyunsaturated Eicosanoid | ALOX5, ALOX15, ALOX15B | SMN1; SMN2 4531/4885ALDH1A1 1023/4885TDP1 3485/4885 |
| US-20120157700-A1 | TRIHYDROXY POLYUNSATURATED EICOSANOID DERIVATIVES | ALOX5, ALOX15, ALOX15B | SMN1; SMN2 4587/4885ALDH1A1 1027/4885TDP1 3414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.