Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10364870 | 0.83 | PDE10A (0.56) | PDE10ARECQLKDM4ECYP1A2ALDH1A1 | |
| SCHEMBL15865964 | 0.75 | KDM4E (0.57) | PDE10ARECQLKDM4ECYP1A2ALDH1A1 | |
| SCHEMBL1463574 | 0.70 | RECQL (0.56) | PDE10ARECQLKDM4ECYP1A2ALDH1A1 | |
| SCHEMBL9975827 | 0.70 | ALDH1A1 (0.70) | PDE10ARECQLKDM4ECYP1A2ALDH1A1 | |
| SCHEMBL16199688 | 0.69 | RECQL (0.59) | RECQLKDM4ECYP1A2ALDH1A1HTT | |
| SCHEMBL15807121 | 0.67 | RECQL (0.76) | PDE10ARECQLKDM4ECYP1A2ALDH1A1 | |
| SCHEMBL16738138 | 0.67 | PDE10A (1.00) | PDE10ARECQLKDM4ECYP1A2ALDH1A1 | |
| SCHEMBL15607655 | 0.67 | PDE10A (1.00) | PDE10ARECQLKDM4ECYP1A2ALDH1A1 | |
| SCHEMBL15549335 | 0.66 | PDE10A (0.63) | PDE10ARECQLKDM4ECYP1A2ALDH1A1 | |
| SCHEMBL15549334 | 0.66 | PDE10A (0.63) | PDE10ARECQLKDM4ECYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120183496-A1 | INHIBITORS OF HEPATITIS C VIRUS POLYMERASE | COCRYSTAL DISCOVERY, INC. (US) | 2012-07-19 | — | — | US | disclosed |
| WO-2012083105-A1 | INHIBITORS OF HEPATITIS C VIRUS POLYMERASE | COCRYSTAL DISCOVERY, INC. (US) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120183496-A1 | INHIBITORS OF HEPATITIS C VIRUS POLYMERASE | POLR2A, POLR2B, POLR2E | PDE10A 2932/4885RECQL 123/4885KDM4E 2970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.