Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 4/20 | 0.43 |
| ▸ | CACNB4 | O00305 | 3/20 | 0.43 |
| ▸ | CACNA1A | O00555 | 3/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.43 |
| ▸ | CACNG3 | O60359 | 3/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.43 |
| ▸ | CACNB3 | P54284 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9976406 | 0.95 | ALDH1A1 (0.54) | ALDH1A1MAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL16478395 | 0.93 | MAPT (0.50) | ALDH1A1MAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL9976402 | 0.92 | ALDH1A1 (0.49) | ALDH1A1MAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL9976397 | 0.91 | MAPT (0.50) | ALDH1A1MAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL9976404 | 0.91 | GAA (0.53) | ALDH1A1MAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL9976400 | 0.87 | ALDH1A1 (0.54) | ALDH1A1MAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL9976399 | 0.87 | MAPT (0.47) | ALDH1A1MAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL13013899 | 0.86 | ALDH1A1 (0.46) | ALDH1A1MAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL9976403 | 0.86 | ALDH1A1 (0.46) | ALDH1A1MAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL9976405 | 0.85 | ALDH1A1 (0.47) | ALDH1A1MAPTSMN1; SMN2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629272-B2 | Tricyclic pyrimidine derivatives as wnt antagonists | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2014-01-14 | — | — | US | disclosed |
| US-8629272-B2 | Tricyclic pyrimidine derivatives as wnt antagonists | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2014-01-14 | — | — | US | disclosed |
| US-20120157481-A1 | TRICYCLIC PYRIMIDINE DERIVATIVES AS WNT ANTAGONISTS | DEUTSCHES KREBSFORSCHUNGSZENTRUM | 2012-06-21 | — | — | US | disclosed |
| US-20120157481-A1 | TRICYCLIC PYRIMIDINE DERIVATIVES AS WNT ANTAGONISTS | DEUTSCHES KREBSFORSCHUNGSZENTRUM | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157481-A1 | TRICYCLIC PYRIMIDINE DERIVATIVES AS WNT ANTAGONISTS | WNT1, WNT3, WNT3A | ALDH1A1 1200/4885MAPT 2558/4885SMN1; SMN2 4395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.