Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.38 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | AHCY | P23526 | 6/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | KLK7 | P49862 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | GMPS | P49915 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9317293 | 0.84 | PI4KA (0.42) | PI4KAPI4K2BPI4K2API4KBADORA1 | |
| SCHEMBL28246105 | 0.73 | ADORA3 (0.45) | PI4KAPI4K2BPI4K2API4KBADORA1 | |
| SCHEMBL11038931 | 0.72 | AHCY (0.40) | PI4KAPI4K2BPI4K2API4KBAHCY | |
| SCHEMBL7613659 | 0.70 | PI4KA (0.43) | PI4KAPI4K2BPI4K2API4KBAHCY | |
| SCHEMBL11459664 | 0.67 | PI4KA (0.48) | PI4KAPI4K2BPI4K2API4KBAHCY | |
| SCHEMBL28035584 | 0.66 | PI4KA (0.42) | PI4KAPI4K2BPI4K2API4KBAHCY | |
| SCHEMBL7788095 | 0.66 | AHCY (0.46) | PI4KAPI4K2BPI4K2API4KBAHCY | |
| SCHEMBL2488747 | 0.66 | ADORA3 (0.49) | PI4KAPI4K2BPI4K2API4KBAHCY | |
| SCHEMBL27343180 | 0.66 | ADORA3 (0.49) | PI4KAPI4K2BPI4K2API4KBAHCY | |
| SCHEMBL28781539 | 0.65 | AHCY (0.45) | PI4KAPI4K2BPI4K2API4KBAHCY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160368944-A1 | LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS | US HEALTH (US) | 2016-12-22 | — | — | US | disclosed |
| US-9453019-B2 | Linked purine pterin HPPK inhibitors useful as antibacterial agents | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2016-09-27 | — | — | US | disclosed |
| US-20150218167-A1 | LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS | US HEALTH (US) | 2015-08-06 | — | — | US | disclosed |
| US-9029344-B2 | Linked purine pterin HPPK inhibitors useful as antibacterial agents | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2015-05-12 | — | — | US | disclosed |
| US-20130172285-A1 | LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2013-07-04 | — | — | US | disclosed |
| EP-2582712-A2 | LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services (US) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011159471-A2 | LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368944-A1 | LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS | PDXK, HPRT1, PLPBP | PI4KA 980/4885PI4K2B 831/4885PI4K2A 838/4885 |
| US-20130172285-A1 | LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS | PDXK, HPRT1, PLPBP | PI4KA 1009/4885PI4K2B 872/4885PI4K2A 893/4885 |
| US-20150218167-A1 | LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS | PDXK, HPRT1, PLPBP | PI4KA 1009/4885PI4K2B 872/4885PI4K2A 893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.