SCHEMBL2488747

SCHEMBL2488747

Nc1ncnc2c1ncn2[C@]1(S(N)(=O)=O)O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 5/20 0.49
ADORA2A P29274 3/20 0.49
PI4KA P42356 2/20 0.49
PI4K2B Q8TCG2 2/20 0.49
PI4K2A Q9BTU6 2/20 0.49
PI4KB Q9UBF8 2/20 0.49
SLC28A1 O00337 2/20 0.49
ADORA1 P30542 2/20 0.49
DPP4 P27487 1/20 0.49
MEN1 O00255 1/20 0.49
MAP3K7 O43318 1/20 0.49
SLC28A2 O43868 1/20 0.49
GAPDH P04406 1/20 0.49
MAPK1 P28482 1/20 0.49
ADORA2B P29275 1/20 0.49
STAT6 P42226 1/20 0.49
KMT2A Q03164 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
DOT1L Q8TEK3 1/20 0.49
SLC29A1 Q99808 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27343180 0.91 ADORA3 (0.49) ADORA3ADORA2API4KAPI4K2BPI4K2A
SCHEMBL11459664 0.90 PI4KA (0.48) ADORA3ADORA2API4KAPI4K2BPI4K2A
SCHEMBL28246105 0.86 ADORA3 (0.45) ADORA3ADORA2API4KAPI4K2BPI4K2A
SCHEMBL17545193 0.84 EHMT1 (0.46) ADORA3ADORA2API4KAPI4K2BPI4K2A
SCHEMBL7613659 0.84 PI4KA (0.43) ADORA3ADORA2API4KAPI4K2BPI4K2A
SCHEMBL5666883 0.84 ADORA3 (0.43) ADORA3ADORA2API4KAPI4K2BPI4K2A
SCHEMBL481525 0.84 ADORA3 (0.55) ADORA3ADORA2API4KAPI4K2BPI4K2A
SCHEMBL31062627 0.84 ADORA3 (0.55) ADORA3ADORA2API4KAPI4K2BPI4K2A
Water SCHEMBL27885621 0.83 ADORA3 (0.54) ADORA3ADORA2API4KAPI4K2BPI4K2A
SCHEMBL9317293 0.83 PI4KA (0.42) ADORA3ADORA2API4KAPI4K2BPI4K2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260109675-A1 COMPOSITIONS AND METHODS FOR ADOPTIVE CELL THERAPY FOR CANCER MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2026-04-23 US disclosed
US-20260103696-A1 COMPOSITIONS AND METHODS FOR ADOPTIVE CELL THERAPY FOR CANCER MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2026-04-16 US disclosed
US-12496310-B2 Compositions and methods for adoptive cell therapy MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2025-12-16 US disclosed
EP-3645561-B1 COMPOSITIONS AND METHODS FOR ADOPTIVE CELL THERAPY FOR CANCER MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2025-05-07 EP disclosed
US-12241097-B2 Compositions and methods for adoptive cell therapy for cancer MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2025-03-04 US disclosed
US-12178830-B2 Compositions and methods for adoptive cell therapy for cancer MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2024-12-31 US disclosed
US-11708353-B2 Inhibitors of prolyl-tRNA-synthetase THE GENERAL HOSPITAL CORPORATION (US) 2023-07-25 US disclosed
US-20230190797-A1 COMPOSITIONS AND METHODS FOR ADOPTIVE CELL THERAPY MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2023-06-22 US disclosed
US-10874686-B2 Anthranilyl-adenosinemonosulfamate analogs and uses thereof MEMORIAL SLOAN-KETTERING CANCER CENTER (US) 2020-12-29 US disclosed
US-20200268794-A1 COMPOSITIONS AND METHODS FOR ADOPTIVE CELL THERAPY MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2020-08-27 US disclosed
US-20170327549-A1 Adenylation Enzyme Inhibitors STICHTING HET NEDERLANDS KANKER INSTITUUT - ANTONI VAN LEEUWENHOEK ZIEKENHUIS (NL) 2017-11-16 US disclosed
EP-3185879-A1 ADENYLATION ENZYME INHIBITORS Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis (NL) 2017-07-05 EP disclosed
WO-2016032332-A1 ADENYLATION ENZYME INHIBITORS STICHTING HET NEDERLANDS KANKER INSTITUUT - ANTONI VAN LEEUWENHOEK ZIEKENHUIS (NL) 2016-03-03 WO disclosed
EP-2376647-B1 MONO CHARGING SYSTEM FOR SELECTIVELY INTRODUCING NON-NATIVE AMINO ACIDS INTO PROTEINS USING AN IN VITRO PROTEIN SYNTHESIS SYSTEM SUTRO BIOPHARMA INC (US) 2014-03-05 EP disclosed
EP-2379578-A1 DUAL CHARGING SYSTEM FOR SELECTIVELY INTRODUCING NON-NATIVE AMINO ACIDS INTO PROTEINS USING AN IN VITRO SYNTHESIS METHOD Sutro Biopharma, Inc. (US) 2011-10-26 EP disclosed
EP-2376647-A1 MONO CHARGING SYSTEM FOR SELECTIVELY INTRODUCING NON-NATIVE AMINO ACIDS INTO PROTEINS USING AN IN VITRO PROTEIN SYNTHESIS SYSTEM Sutro Biopharma, Inc. (US) 2011-10-19 EP disclosed
WO-2010081111-A1 MONO CHARGING SYSTEM FOR SELECTIVELY INTRODUCING NON-NATIVE AMINO ACIDS INTO PROTEINS USING AN IN VITRO PROTEIN SYNTHESIS SYSTEM SUTRO BIOPHARMA, INC. (US) 2010-07-15 WO disclosed
WO-2010081110-A1 DUAL CHARGING SYSTEM FOR SELECTIVELY INTRODUCING NON-NATIVE AMINO ACIDS INTO PROTEINS USING AN IN VITRO SYNTHESIS METHOD SUTRO BIOPHARMA, INC. (US) 2010-07-15 WO disclosed
EP-1960518-A2 ANTIBACTERIAL AGENTS REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2008-08-27 EP disclosed
WO-2007067559-A2 ANTIBACTERIAL AGENTS REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2007-06-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10874686-B2 Anthranilyl-adenosinemonosulfamate analogs and uses thereof ATIC, SLC35B2, ADORA1 ADORA3 6/4885ADORA2A 5/4885PI4KA 2340/4885
US-20260103696-A1 COMPOSITIONS AND METHODS FOR ADOPTIVE CELL THERAPY FOR CANCER CCRL2, CCR3, LY6K ADORA3 119/4885ADORA2A 383/4885PI4KA 1274/4885
US-12496310-B2 Compositions and methods for adoptive cell therapy HAVCR2, CD4, CCR1 ADORA3 2519/4885ADORA2A 1309/4885PI4KA 1903/4885
US-12241097-B2 Compositions and methods for adoptive cell therapy for cancer CD2, PBK, CD4 ADORA3 2151/4885ADORA2A 1239/4885PI4KA 1808/4885
US-11708353-B2 Inhibitors of prolyl-tRNA-synthetase GARS1, AARS1, NSUN3 ADORA3 3593/4885ADORA2A 3583/4885PI4KA 3019/4885
US-20260109675-A1 COMPOSITIONS AND METHODS FOR ADOPTIVE CELL THERAPY FOR CANCER IL2RA, CCR3, CD4 ADORA3 1034/4885ADORA2A 2083/4885PI4KA 1915/4885
US-20230190797-A1 COMPOSITIONS AND METHODS FOR ADOPTIVE CELL THERAPY HAVCR2, CD4, CCR1 ADORA3 2519/4885ADORA2A 1309/4885PI4KA 1903/4885
US-20200268794-A1 COMPOSITIONS AND METHODS FOR ADOPTIVE CELL THERAPY HAVCR2, CD4, CCR1 ADORA3 2519/4885ADORA2A 1309/4885PI4KA 1903/4885
US-20170327549-A1 Adenylation Enzyme Inhibitors ADSL, APEH, AHCY ADORA3 134/4885ADORA2A 216/4885PI4KA 2183/4885
US-12178830-B2 Compositions and methods for adoptive cell therapy for cancer CD2, PBK, CD4 ADORA3 2151/4885ADORA2A 1239/4885PI4KA 1808/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.