Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | GRK2 | P25098 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3762000 | 0.78 | HPGDS (0.47) | HSP90AA1MAPTDYRK1BFGFR1 | |
| SCHEMBL8390694 | 0.77 | CYP4F2 (0.56) | KDM4EHSP90AA1MAPTMAPK1NPSR1 | |
| SCHEMBL8390697 | 0.76 | MAOB (0.62) | MRGPRX4CYP4F2CYP4A11BCHENR4A2 | |
| SCHEMBL379281 | 0.74 | MAOB (0.67) | MRGPRX4CYP4F2CYP4A11BCHENR4A2 | |
| SCHEMBL4051954 | 0.73 | AKT1 (0.54) | CDC7KDM4EHSP90AA1MAPTMAPK1 | |
| SCHEMBL2137838 | 0.73 | MRGPRX4 (0.69) | MRGPRX4CYP4F2CYP4A11BCHENR4A2 | |
| SCHEMBL3757242 | 0.73 | METAP2 (0.47) | DYRK1BROCK2FGFR1FGFR2FGFR3 | |
| SCHEMBL2570284 | 0.72 | CDC7 (0.61) | CDC7KDM4EHSP90AA1MAPTMAPK1 | |
| SCHEMBL29463390 | 0.72 | ALOX5 (0.58) | CDC7KDM4EHSP90AA1MAPTMAPK1 | |
| SCHEMBL4977897 | 0.72 | ALOX5 (0.58) | CDC7KDM4EHSP90AA1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076338-B2 | Such as 6-(4-phenylpiperazin-1-yl)-9H-purine; cell proliferation/differentiation | EXELIXIS, INC. (US) | 2011-12-13 | — | — | US | disclosed |