Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 3/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 5/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 5/20 | 0.36 |
| ▸ | HCK | P08631 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.36 |
| ▸ | PRKDC | P78527 | 2/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.36 |
| ▸ | CSK | P41240 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30095708 | 0.90 | MERTK (0.37) | MERTKABL1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL14617266 | 0.75 | ABL1 (0.51) | PRKD3PRKD1PRKD2ABL1LCK | |
| SCHEMBL4185095 | 0.75 | ALDH1A1 (0.41) | SRCPIK3CAMTORPIK3CGJAK2 | |
| SCHEMBL9982985 | 0.71 | TDP1 (0.46) | — | |
| SCHEMBL31429286 | 0.71 | ADRA2A (0.48) | MERTKPRKD3PRKD1PRKD2 | |
| SCHEMBL2244617 | 0.70 | XDH (0.46) | ABL1PIK3CDEGFR | |
| SCHEMBL31299875 | 0.70 | MAPK8 (0.46) | MERTKSRCKDRJAK2JAK1 | |
| Hydrochloric Acid SCHEMBL31299823 | 0.69 | MAPK8 (0.45) | MERTKSRCKDRJAK2JAK1 | |
| SCHEMBL22664678 | 0.69 | MAP2K5 (0.46) | LCKSRCHCKMTORCSK | |
| SCHEMBL19222864 | 0.68 | CRHR1 (0.40) | MERTKABL1HRH3HRH4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076338-B2 | Such as 6-(4-phenylpiperazin-1-yl)-9H-purine; cell proliferation/differentiation | EXELIXIS, INC. (US) | 2011-12-13 | — | — | US | disclosed |