Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.49 |
| ▸ | LIPG | Q9Y5X9 | 9/20 | 0.49 |
| ▸ | LPL | P06858 | 8/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | F11 | P03951 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | P4HB | P07237 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23259140 | 0.92 | DGAT1 (0.52) | DGAT1LIPGLPLKEAP1NFE2L2 | |
| SCHEMBL20510673 | 0.82 | LPL (0.49) | DGAT1LIPGLPLF11EGFR | |
| SCHEMBL258005 | 0.81 | DGAT1 (0.64) | DGAT1LIPGLPLF11CA1 | |
| SCHEMBL14673623 | 0.81 | SMN1; SMN2 (0.46) | DGAT1LIPGLPLKEAP1NFE2L2 | |
| SCHEMBL9985674 | 0.79 | HTT (0.44) | DGAT1KEAP1NFE2L2 | |
| SCHEMBL298401 | 0.79 | DGAT1 (0.72) | DGAT1LIPGLPLCA1CA2 | |
| SCHEMBL257901 | 0.78 | LIPG (0.59) | DGAT1LIPGLPLKEAP1NFE2L2 | |
| SCHEMBL17474563 | 0.78 | DGAT1 (0.54) | DGAT1LIPGLPLEGFR | |
| SCHEMBL18874632 | 0.77 | NPC1 (0.45) | DGAT1LIPGLPLF11EGFR | |
| SCHEMBL16690435 | 0.77 | DGAT1 (0.39) | DGAT1LIPGLPLKEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889638-B2 | Stimulus-triggered prodrugs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-11-18 | — | — | US | disclosed |
| US-8889638-B2 | Stimulus-triggered prodrugs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-11-18 | — | — | US | disclosed |
| US-8889638-B2 | Stimulus-triggered prodrugs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-11-18 | — | — | US | disclosed |
| US-20110312905-A1 | STIMULUS-TRIGGERED PRODRUGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-12-22 | — | — | US | disclosed |
| US-20110312905-A1 | STIMULUS-TRIGGERED PRODRUGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-12-22 | — | — | US | disclosed |
| US-20110312905-A1 | STIMULUS-TRIGGERED PRODRUGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312905-A1 | STIMULUS-TRIGGERED PRODRUGS | PREP, ADAM10, DNPEP | DGAT1 1934/4885LIPG 488/4885LPL 564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.