Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27909350 | 0.77 | OPRM1 (0.43) | OPRM1OPRK1OPRL1ADRB1HTR6 | |
| SCHEMBL11227084 | 0.72 | HTR2C (0.44) | ADRB1PARP1HTR2CHTR2BHTR2A | |
| SCHEMBL12069837 | 0.71 | SLC6A4 (0.38) | OPRM1OPRK1OPRL1ADRB1HTR6 | |
| SCHEMBL10811594 | 0.71 | TP53 (0.43) | SLC6A4HTR1AHTR2CHTR2BGPBAR1 | |
| Hydrochloric Acid SCHEMBL11030525 | 0.71 | HTR2C (0.43) | PARP1HTR2CHTR2BHTR2A | |
| SCHEMBL27836228 | 0.69 | DAO (0.46) | OPRM1OPRK1OPRL1ADRB1HTR6 | |
| SCHEMBL23609411 | 0.69 | HTR6 (0.56) | OPRM1OPRK1OPRL1ADRB1HTR6 | |
| SCHEMBL30099664 | 0.69 | HTR6 (0.56) | OPRM1OPRK1OPRL1ADRB1HTR6 | |
| SCHEMBL10119880 | 0.67 | SLC6A4 (0.49) | OPRM1OPRK1ADRB1HTR6DRD2 | |
| SCHEMBL32691857 | 0.64 | GAA (0.50) | OPRM1OPRK1OPRL1HTR6GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582681-A1 | PIPERIDINYL SUBSTITUTED 1,3-DIHYDRO-BENZOIMIDAZOL-2-YLIDENEAMINE DERIVATIVES | Novartis AG (CH) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011157793-A1 | PIPERIDINYL SUBSTITUTED 1,3-DIHYDRO-BENZOIMIDAZOL-2-YLIDENEAMINE DERIVATIVES | NOVARTIS AG (CH) | 2011-12-22 | — | — | WO | disclosed |