Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8568557 | 0.80 | TSHR (0.60) | TSHREGFRSRCKDM4EL3MBTL1 | |
| SCHEMBL25433493 | 0.71 | TSHR (0.51) | TSHRKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL4236344 | 0.71 | SMN1; SMN2 (0.47) | KDM4EL3MBTL1SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL4208219 | 0.70 | KDM4E (0.62) | TSHREGFRSRCKDM4EL3MBTL1 | |
| SCHEMBL1421429 | 0.69 | CCR2 (0.51) | EGFRKDM4ESMN1; SMN2ALDH1A1NR4A2 | |
| SCHEMBL1408375 | 0.68 | SMN1; SMN2 (0.56) | KDM4EL3MBTL1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL7607181 | 0.68 | KMT2A (0.43) | KDM4ESMN1; SMN2ALDH1A1HPGDHDAC1 | |
| SCHEMBL30234519 | 0.68 | MCL1 (0.45) | TSHRPLK1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL27527098 | 0.68 | L3MBTL1 (0.44) | TSHRKDM4EL3MBTL1ALDH1A1HSD17B10 | |
| SCHEMBL9987683 | 0.68 | MCL1 (0.45) | TSHRPLK1KDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011163195-A1 | FUSED PYRROLE DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-12-29 | — | — | WO | disclosed |