Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 19/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15159024 | 0.85 | SLC22A12 (0.48) | SLC22A12 | |
| SCHEMBL9994877 | 0.80 | PIN1 (0.45) | SLC22A12TP53 | |
| SCHEMBL16927379 | 0.80 | SLC22A12 (0.66) | SLC22A12 | |
| SCHEMBL10570182 | 0.77 | TP53 (0.45) | SLC22A12TP53 | |
| SCHEMBL16485890 | 0.76 | LATS1 (0.40) | — | |
| SCHEMBL9988007 | 0.75 | SLC22A12 (0.72) | SLC22A12 | |
| SCHEMBL21350294 | 0.75 | SLC22A12 (0.59) | SLC22A12 | |
| SCHEMBL9987803 | 0.74 | TP53 (0.49) | SLC22A12TP53 | |
| SCHEMBL9993826 | 0.74 | SLC22A12 (0.50) | SLC22A12 | |
| SCHEMBL27907670 | 0.74 | PIN1 (0.40) | SLC22A12TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103864677-B | Thioacetic acid salt compound, compoistion and method of use | ARDEA BIOSCIENCES, INC. (US) | 2016-05-18 | — | — | CN | claimed |
| EP-2712861-B1 | Thioacetate compounds, compositions and methods of use | ARDEA BIOSCIENCES INC (US) | 2015-07-29 | — | — | EP | claimed |
| CN-103864677-A | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES INC | 2014-06-18 | — | — | CN | claimed |
| US-20210171466-A1 | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | AREDEA BIOSCIENCES, INC. | 2021-06-10 | — | — | US | disclosed |
| US-10919858-B2 | Thioacetate compounds, compositions and methods of use | ARDEA BIOSCIENCES, INC (US) | 2021-02-16 | — | — | US | disclosed |
| US-10570095-B2 | 3,4-di-substituted pyridine compound, methods of using and compositions comprising the same | ARDEA BIOSCIENCES, INC. (US) | 2020-02-25 | — | — | US | disclosed |
| EP-3611167-A1 | THIOACETATE COMPOUND AND METHODS OF USE | Ardea Biosciences, Inc. (US) | 2020-02-19 | — | — | EP | disclosed |
| EP-3611167-A1 | THIOACETATE COMPOUND AND METHODS OF USE | Ardea Biosciences, Inc. (US) | 2020-02-19 | — | — | EP | disclosed |
| EP-3501520-A1 | 3,4-DI-SUBSTITUTED PYRIDINE COMPOUND, METHODS OF USING AND COMPOSITIONS COMPRISING THE SAME | Ardea Biosciences, Inc. (US) | 2019-06-26 | — | — | EP | disclosed |
| US-20190185431-A1 | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES, INC. | 2019-06-20 | — | — | US | disclosed |
| US-20190135756-A1 | 3,4-DI-SUBSTITUTED PYRIDINE COMPOUND, METHODS OF USING AND COMPOSITIONS COMPRISING THE SAME | ARDEA BIOSCIENCES, INC. | 2019-05-09 | — | — | US | disclosed |
| US-20130202573-A1 | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES, INC. (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130202573-A1 | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES, INC. (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130202573-A1 | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES, INC. (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130203779-A1 | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES, INC. (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130203779-A1 | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES, INC. (US) | 2013-08-08 | — | — | US | disclosed |
| WO-2013067425-A1 | 3,4-DI-SUBSTITUTED PYRIDINE COMPOUND, METHODS OF USING AND COMPOSITIONS COMPRISING THE SAME | ARDEA BIOSCIENCES INC. (US) | 2013-05-10 | — | — | WO | disclosed |
| EP-2585437-A2 | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Ardea Biosciences, Inc. (US) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011159839-A2 | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES, INC. (US) | 2011-12-22 | — | — | WO | disclosed |
| WO-2011159839-A2 | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES, INC. (US) | 2011-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130202573-A1 | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | TXN, TXN2, XDH | SLC22A12 757/4885TP53 1944/4885 |
| US-10570095-B2 | 3,4-di-substituted pyridine compound, methods of using and compositions comprising the same | PLPBP, XDH, TPMT | SLC22A12 603/4885TP53 3324/4885 |
| US-20210171466-A1 | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | TXN, TXN2, XDH | SLC22A12 757/4885TP53 1944/4885 |
| US-20190135756-A1 | 3,4-DI-SUBSTITUTED PYRIDINE COMPOUND, METHODS OF USING AND COMPOSITIONS COMPRISING THE SAME | PLPBP, XDH, TPMT | SLC22A12 603/4885TP53 3324/4885 |
| US-10919858-B2 | Thioacetate compounds, compositions and methods of use | TXN, TXN2, XDH | SLC22A12 757/4885TP53 1944/4885 |
| US-20130203779-A1 | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | TXN, TXN2, XDH | SLC22A12 757/4885TP53 1944/4885 |
| US-20190185431-A1 | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | TXN, TXN2, XDH | SLC22A12 757/4885TP53 1944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.