Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4280144 | 0.92 | PDPK1 (0.41) | ADRA1ATAS1R3TAS1R1TAS1R2IDO1 | |
| SCHEMBL9987957 | 0.83 | TAS1R3 (0.47) | GID4TAS1R3TAS1R1MAPK1MAPK14 | |
| SCHEMBL9988082 | 0.79 | ADRA2A (0.43) | GID4ADRA2AADRA1ACYP2D6ADRA1D | |
| SCHEMBL4280697 | 0.75 | TAS1R3 (0.45) | ADRA1ATAS1R3TAS1R1TAS1R2MAPK1 | |
| SCHEMBL4279564 | 0.75 | ADRA1A (0.38) | ADRA1ATAS1R3TAS1R1TAS1R2IDO1 | |
| SCHEMBL833179 | 0.75 | ADRA2A (0.42) | GID4ADRA2AADRA1ACYP2D6ADRA1D | |
| SCHEMBL10359793 | 0.73 | GID4 (0.51) | GID4ADRA2AADRA1ACYP2D6ADRA1D | |
| SCHEMBL4277910 | 0.71 | ADRA1A (0.39) | ADRA1ATAS1R3TAS1R1TAS1R2IDO1 | |
| SCHEMBL4275619 | 0.70 | PIN1 (0.43) | ADRA1ATAS1R3TAS1R1TAS1R2IDO1 | |
| SCHEMBL10501682 | 0.70 | ADRA2A (0.50) | GID4ADRA2AADRA1ACYP2D6ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2397462-A2 | Compounds, compositions and methods of treatment for heart failure | Cytokinetics, Inc. (US) | 2011-12-21 | — | — | EP | disclosed |