Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.57 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | WDR5 | P61964 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28784798 | 0.89 | LMNA (0.68) | LMNASMN1; SMN2KEAP1NFE2L2CA12 | |
| SCHEMBL9997531 | 0.88 | KMT2A (0.66) | LMNASMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL3561138 | 0.81 | SMN1; SMN2 (0.59) | LMNASMN1; SMN2KEAP1NFE2L2CA12 | |
| SCHEMBL9997386 | 0.81 | ALDH1A1 (0.62) | LMNAMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL9997964 | 0.81 | FABP4 (0.60) | LMNASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL3560739 | 0.80 | SMN1; SMN2 (0.57) | LMNASMN1; SMN2KEAP1NFE2L2CA12 | |
| SCHEMBL3559521 | 0.79 | SMN1; SMN2 (0.56) | LMNASMN1; SMN2KEAP1NFE2L2CA12 | |
| SCHEMBL28637555 | 0.79 | KMT2A (0.58) | MEN1KMT2AGAAALDH1A1KDM4E | |
| SCHEMBL9996881 | 0.79 | ALDH1A1 (0.62) | LMNASMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL9997084 | 0.77 | LMNA (0.68) | LMNASMN1; SMN2CA12CA9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011161201-A1 | BISARYLSULFONAMIDES USEFUL AS KINASE INHIBITORS IN THE TREATMENT OF INFLAMMATION AND CANCER | KANCERA AB (SE) | 2011-12-29 | — | — | WO | disclosed |