Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 1/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 5/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CD38 | P28907 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.40 |
| ▸ | ASPH | Q12797 | 1/20 | 0.39 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19970131 | 0.82 | VNN1 (0.49) | VNN1CNR2DPP4SPHK2SPHK1 | |
| SCHEMBL2713154 | 0.81 | KDM4E (0.59) | GRM4CNR2KDM4EALDH1A1HPGD | |
| SCHEMBL3714496 | 0.78 | KDM4E (0.59) | GRM4CNR2KDM4EALDH1A1HPGD | |
| SCHEMBL4925913 | 0.76 | VNN1 (0.49) | VNN1CNR2DPP4SPHK2SPHK1 | |
| SCHEMBL4925911 | 0.76 | VNN1 (0.49) | VNN1CNR2DPP4SPHK2SPHK1 | |
| SCHEMBL3716905 | 0.75 | ALDH1A1 (0.62) | GRM4KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5859584 | 0.71 | HTT (0.54) | GRM4KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10017975 | 0.70 | CTSS (0.50) | GRM4CNR2KDM4EALDH1A1CD38 | |
| SCHEMBL496596 | 0.70 | KDM4C (0.54) | KDM4EALDH1A1HPGDHSD17B10ASPH | |
| SCHEMBL31678687 | 0.70 | KDM4E (0.46) | GRM4CNR2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180071267-A1 | AMELIORATION OF NEURAL DEFICITS ASSOCIATED WITH DIABETES | NEURALSTEM, INC. (US) | 2018-03-15 | — | — | US | disclosed |
| WO-2018048927-A1 | AMELIORATION OF NEURAL DEFICITS ASSOCIATED WITH DIABETES | NEURALSTEM, INC. (US) | 2018-03-15 | — | — | WO | disclosed |
| US-20180071267-A1 | AMELIORATION OF NEURAL DEFICITS ASSOCIATED WITH DIABETES | NEURALSTEM, INC. (US) | 2018-03-15 | — | — | US | disclosed |
| US-8846914-B2 | Compositions to effect neuronal growth | NEURALSTEM, INC. (US) | 2014-09-30 | — | — | US | disclosed |
| US-8846914-B2 | Compositions to effect neuronal growth | NEURALSTEM, INC. (US) | 2014-09-30 | — | — | US | disclosed |
| US-20140147424-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | NEURALSTEM, INC. (US) | 2014-05-29 | — | — | US | disclosed |
| US-20140147424-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | NEURALSTEM, INC. (US) | 2014-05-29 | — | — | US | disclosed |
| US-8674098-B2 | Compositions to effect neuronal growth | NEURALSTEM, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-8674098-B2 | Compositions to effect neuronal growth | NEURALSTEM, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-20130195816-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | NEURALSTEM, INC. (US) | 2013-08-01 | — | — | US | disclosed |
| US-20110135612-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | NEURALSTEM, INC. | 2011-06-09 | — | — | US | disclosed |
| US-20110135612-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | NEURALSTEM, INC. | 2011-06-09 | — | — | US | disclosed |
| US-20110052552-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | NEURALSTEM, INC. | 2011-03-03 | — | — | US | disclosed |
| US-20110052552-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | NEURALSTEM, INC. | 2011-03-03 | — | — | US | disclosed |
| US-7858628-B2 | inhibiting neuronal death, inducing proliferation and differentiation of a neuronal progenitor cell into a neuron and increasing the number of neurons, in humans | NEURALSTEM, INC. (US) | 2010-12-28 | — | — | US | disclosed |
| US-7858628-B2 | inhibiting neuronal death, inducing proliferation and differentiation of a neuronal progenitor cell into a neuron and increasing the number of neurons, in humans | NEURALSTEM, INC. (US) | 2010-12-28 | — | — | US | disclosed |
| US-20100034784-A1 | inhibiting neuronal death, inducing proliferation and differentiation of a neuronal progenitor cell into a neuron and increasing the number of neurons, in humans | NEURALSTEM, INC. (US) | 2010-02-11 | — | — | US | disclosed |
| US-20100034784-A1 | inhibiting neuronal death, inducing proliferation and differentiation of a neuronal progenitor cell into a neuron and increasing the number of neurons, in humans | NEURALSTEM, INC. (US) | 2010-02-11 | — | — | US | disclosed |
| US-7560553-B1 | 1-(Pyrid-4-yl-methyl-),4-((6-piperazino)pyrid-5-yl)-piperazine; proliferation/differentiation of human hippocampal multipotent stem/progenitor cells and neuronal progenitors; drug screening; learning enhancement; cognition activators; Alzheimer's disease; antidepressants; brain trauma; neuroprotectants | NEURALSTEM, INC. (US) | 2009-07-14 | — | — | US | disclosed |
| US-7560553-B1 | 1-(Pyrid-4-yl-methyl-),4-((6-piperazino)pyrid-5-yl)-piperazine; proliferation/differentiation of human hippocampal multipotent stem/progenitor cells and neuronal progenitors; drug screening; learning enhancement; cognition activators; Alzheimer's disease; antidepressants; brain trauma; neuroprotectants | NEURALSTEM, INC. (US) | 2009-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100034784-A1 | inhibiting neuronal death, inducing proliferation and differentiation of a neuronal progenitor cell into a neuron and increasing the number of neurons, in humans | DCX, MKI67, INA | VNN1 3635/4885GRM4 152/4885CNR2 1996/4885 |
| US-20140147424-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | GAP43, NGF, NEFM | VNN1 2074/4885GRM4 95/4885CNR2 2502/4885 |
| US-20180071267-A1 | AMELIORATION OF NEURAL DEFICITS ASSOCIATED WITH DIABETES | NLN, CHAT, GPR119 | VNN1 267/4885GRM4 201/4885CNR2 397/4885 |
| US-20110052552-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | GAP43, NGF, NEFM | VNN1 2527/4885GRM4 133/4885CNR2 2704/4885 |
| US-20110135612-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | GAP43, NGF, NEFM | VNN1 2074/4885GRM4 95/4885CNR2 2502/4885 |
| US-20130195816-A1 | COMPOSITIONS TO EFFECT NEURONAL GROWTH | GAP43, NGF, NEFM | VNN1 2074/4885GRM4 95/4885CNR2 2502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.