ADCY4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2658897	0.62	9/20
SCHEMBL2657749	0.81	8/20
SCHEMBL2658721	0.74	8/20
SCHEMBL2658383	0.63	8/20
SCHEMBL2657546	0.61	8/20
SCHEMBL2657983	0.60	8/20
SCHEMBL2657082	0.74	7/20
SCHEMBL2657077	0.60	7/20
SCHEMBL1919194	0.53	7/20
SCHEMBL2653753	0.51	7/20
SCHEMBL2654576	0.51	7/20
SCHEMBL2655409	0.51	7/20
SCHEMBL2655997	0.49	7/20
SCHEMBL2656673	0.49	7/20
SCHEMBL2657984	0.64	6/20
SCHEMBL2658531	0.60	6/20
SCHEMBL2653428	0.58	6/20
SCHEMBL2653879	0.57	6/20
SCHEMBL2657305	0.52	6/20
SCHEMBL2656182	0.52	6/20

Clinical trials — most relevant to ADCY4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients	PHASE1/PHASE2	WITHDRAWN
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia	PHASE1/PHASE2	COMPLETED
Title: Evaluation of a Novel PET Radioligand for Phosphodiesterase-4D (PDE4D)	PHASE1/PHASE2	COMPLETED
Discovery and Validation of Genetic Variants Affecting Microglial Activation in Alzheimer's Disease	PHASE2	ACTIVE_NOT_RECRUITING
Carbidopa-levodopa in Neovascular AMD	PHASE2	COMPLETED
PDE5 Inhibition for Obesity-Related Cardiometabolic Dysfunction	PHASE2	COMPLETED
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals	PHASE1/PHASE2	COMPLETED
PET Whole Body Biodistribution and Test Retest Bain Imaging Studies Using a Phosphodiesterase 4 Inhibitor (R)-[11C]Rolipram	PHASE1	COMPLETED
Effect of Gene Variants on Dopamine Receptor Natriuretic Responses	PHASE1	UNKNOWN
Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism.	PHASE1	COMPLETED
Caffeine Efficacy in ADCY5-related Dyskinesia	nan	UNKNOWN
Pilot Study on Caffeine Efficiency in ADCY5-related Dyskinesia	nan	COMPLETED
Assessment of ADCY5-related Movement Disorders With Motion SENSors	nan	COMPLETED
Stress and Treatment Response in Puerto Rican Children With Asthma	nan	COMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms	nan	UNKNOWN
Clinical Intervention in Alcohol Use Disorder	nan	COMPLETED
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
PACAP Induced Migraine Attacks in Patients With High and Low Genetic Load	nan	COMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan	nan	ENROLLING_BY_INVITATION
Effect of Intraperitoneal Bupivacaine with Dexmedotomidine or Fentanyl for Post-Operative Analgesia Following Laparoscopy in Pediatric Patients	nan	NOT_YET_RECRUITING
PDE3B in Metabolic Regulation	nan	ENROLLING_BY_INVITATION
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)	nan	RECRUITING
Vanderbilt Childhood Obesity Registry	nan	COMPLETED
Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists.	nan	RECRUITING
Insulin Detemir in Obesity Management	nan	ACTIVE_NOT_RECRUITING
Poor Sleep and Inflammation in HIV-Infected Adults	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ADCY4 binder may also engage these)

Protein	Name	Similarity
Q91WF3	—	1.000	Q91WF3 →
P26770	—	1.000	P26770 →
ADCY7	Adenylate cyclase type 7 (EC 4.6.1.1) (ATP py	0.997	landscape →
ADCY1	Adenylate cyclase type 1	0.994	landscape →
ADCY2	Adenylate cyclase type 2	0.994	landscape →
O88444	—	0.994	O88444 →
Q80TL1	—	0.994	Q80TL1 →
P19754	—	0.993	P19754 →
P51829	—	0.993	P51829 →
ADCY6	Adenylate cyclase type 6 (EC 4.6.1.1) (ATP py	0.992	landscape →
Q29450	—	0.991	Q29450 →
P40146	—	0.991	P40146 →
P30804	—	0.990	P30804 →
ADCY3	Adenylate cyclase type 3	0.990	landscape →
P26769	—	0.990	P26769 →
ADCY8	Adenylate cyclase type 8	0.988	landscape →
Q01341	—	0.988	Q01341 →
P32870	—	0.988	P32870 →
Q03343	—	0.987	Q03343 →
P97490	—	0.987	P97490 →
P54310	—	0.987	P54310 →
Q9R101	—	0.985	Q9R101 →
JAK3	Tyrosine-protein kinase JAK3	0.985	landscape →
P51840	—	0.985	P51840 →
P51839	—	0.985	P51839 →
Q8VHH7	—	0.985	Q8VHH7 →
D3ZEY4	—	0.984	D3ZEY4 →
P21932	—	0.984	P21932 →
B0R0W9	—	0.984	B0R0W9 →
Q68J42	—	0.984	Q68J42 →