Hydrochloric Acid

Hydrochloric Acid

SCHEMBL143255

Cl.NCCCOC(=O)/C=C/c1ccccc1

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAOB known ✓ P27338 1/20 0.54
AKR1B10 O60218 6/20 0.63
AKR1B1 P15121 6/20 0.63
LMNA P02545 3/20 0.58
ALDH1A1 P00352 1/20 0.57
MEN1 O00255 2/20 0.55
KMT2A Q03164 2/20 0.55
APP P05067 1/20 0.53
CA12 O43570 1/20 0.50
CA4 P22748 1/20 0.50
CA6 P23280 1/20 0.50
CA5A P35218 1/20 0.50
CA7 P43166 1/20 0.50
CA9 Q16790 1/20 0.50
CA14 Q9ULX7 1/20 0.50
CA5B Q9Y2D0 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.49
ALOX5 P09917 1/20 0.48
RAB9A P51151 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL143254 1.00 AKR1B10 (0.63) AKR1B10AKR1B1LMNAALDH1A1MEN1
SCHEMBL144597 0.98 AKR1B10 (0.65) AKR1B10AKR1B1LMNAALDH1A1MEN1
SCHEMBL144598 0.98 AKR1B10 (0.65) AKR1B10AKR1B1LMNAALDH1A1MEN1
Hydrochloric Acid SCHEMBL1746113 0.95 AKR1B10 (0.61) AKR1B10AKR1B1LMNAALDH1A1MEN1
Hydrochloric Acid SCHEMBL1746110 0.95 AKR1B10 (0.61) AKR1B10AKR1B1LMNAALDH1A1MEN1
Hydrochloric Acid SCHEMBL2340303 0.94 AKR1B10 (0.60) AKR1B10AKR1B1LMNAALDH1A1MEN1
Hydrochloric Acid SCHEMBL1744179 0.94 AKR1B10 (0.60) AKR1B10AKR1B1LMNAALDH1A1MEN1
Hydrochloric Acid SCHEMBL1744177 0.94 AKR1B10 (0.60) AKR1B10AKR1B1LMNAALDH1A1MEN1
Hydrochloric Acid SCHEMBL1744661 0.94 AKR1B10 (0.60) AKR1B10AKR1B1LMNAALDH1A1MEN1
Hydrochloric Acid SCHEMBL2340300 0.94 AKR1B10 (0.60) AKR1B10AKR1B1LMNAALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150094280-A1 PHARMACEUTICAL AGENT HAVING LONG-LASTING EFFECT OF TREATING ARTHRITIC DISORDERS SEIKAGAKU CORPORATION (JP) 2015-04-02 US claimed
US-20220370630-A1 TRANSMUCOSAL DELIVERY SYSTEM FOR PHARMACEUTICAL ACTIVE INGREDIENT TO SUBMUCOSAL TISSUE OF BLADDER SEIKAGAKU CORPORATION (JP) 2022-11-24 US disclosed
US-11472891-B2 Photocrosslinkable alginic acid derivative MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2022-10-18 US disclosed
CN-111918881-B Novel photocrosslinkable alginic acid derivative 持田制药株式会社 2022-08-12 CN disclosed
EP-4039279-A1 TRANSMUCOSAL DELIVERY SYSTEM FOR MEDICINAL ACTIVE INGREDIENT TO SUBMUCOSA OF BLADDER Seikagaku Corporation (JP) 2022-08-10 EP disclosed
CN-111918881-A Novel photocrosslinkable alginic acid derivative 持田制药株式会社 2020-11-10 CN disclosed
US-20180289730-A1 AGENT FOR APPLYING TO MUCOSA AND METHOD FOR THE PRODUCTION THEREOF SEIKAGAKU CORPORATION (JP) 2018-10-11 US disclosed
US-9616087-B2 Pharmaceutical agent having long-lasting effect of treating arthritic disorders SEIKAGAKU CORPORATION (JP) 2017-04-11 US disclosed
EP-1942912-B1 AGENT FOR APPLYING TO MUCOSA AND METHOD FOR PRODUCTION THEREOF SEIKAGAKU KOGYO CO LTD (JP) 2016-12-14 EP disclosed
EP-1794192-B1 PHOTOREACTIVE POLYSACCHARIDE, PHOTOCROSSLINKED POLYSACCHARIDE PRODUCTS, THE METHOD OF MAKING THEM AND MEDICAL MATERIALS MADE THEREFROM SEIKAGAKU KOGYO CO LTD (JP) 2016-05-04 EP disclosed
US-20070009579-A1 Polysaccharide pseudo-sponge SEIKAGAKU COROPRATION (JP) 2007-01-11 US disclosed
US-20060252925-A1 Photocrosslinked polysaccharide composition and process for producing the same SEIKAGAKU CORPORATION (JP) 2006-11-09 US disclosed
EP-1666503-A1 POLYSACCHARIDE PSEUDO-SPONGE SEIKAGAKU CORPORATION (JP) 2006-06-07 EP disclosed
WO-2006030965-A1 PHOTOREACTIVE POLYSACCHARIDE, PHOTOCROSSLINKED POLYSACCHARIDE PRODUCTS, THE METHOD OF MAKING THEM AND MEDICAL MATERIALS THEREFROM SEIKAGAKU CORPORATION (JP) 2006-03-23 WO disclosed
US-20060057098-A1 PHOTOREACTIVE POLYSACCHARIDE, PHOTOCROSSLINKED POLYSACCHARIDE PRODUCT AND METHOD OF MAKING SAME AND MEDICAL MATERIALS MADE FROM THE CROSSLINKED POLYSACCHARIDE SEIKAGAKU CORPORATION (JP) 2006-03-16 US disclosed
EP-1217008-B1 Photocurable hyaluronic acid derivative and process for producing the same, and photocured crosslinked hyaluronic acid derivative and medical material using the same SEIKAGAKU KOGYO CO LTD (JP) 2006-03-01 EP disclosed
EP-1607405-A1 PHOTOCROSSLINKED POLYSACCHARIDE COMPOSITION AND PROCESS FOR PRODUCING THE SAME SEIKAGAKU CORPORATION (JP) 2005-12-21 EP disclosed
US-6602859-B2 Hydrophilic property and having an improved filterability of the aqueous solution SEIKAGAKU CORPORATION (JP) 2003-08-05 US disclosed
US-20020143121-A1 Photocurable hyaluronic acid derivative and process for producing the same, and photocured crosslinked-hyaluronic acid derivative and medical material using the same SEIKAGAKU CORPORATION (JP) 2002-10-03 US disclosed
EP-1217008-A1 Photocurable hyaluronic acid derivative and process for producing the same, and photocured crosslinked hyaluronic acid derivative and medical material using the same SEIKAGAKU CORPORATION (JP) 2002-06-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070009579-A1 Polysaccharide pseudo-sponge CD44, SI, ALG1 MAOB 2844/4885AKR1B10 3257/4885AKR1B1 3962/4885
US-20180289730-A1 AGENT FOR APPLYING TO MUCOSA AND METHOD FOR THE PRODUCTION THEREOF CD44, FABP2, MUC1 MAOB 3054/4885AKR1B10 3240/4885AKR1B1 3848/4885
US-20060252925-A1 Photocrosslinked polysaccharide composition and process for producing the same ALG1, CSGALNACT1, PROC MAOB 1969/4885AKR1B10 2186/4885AKR1B1 2828/4885
US-20220370630-A1 TRANSMUCOSAL DELIVERY SYSTEM FOR PHARMACEUTICAL ACTIVE INGREDIENT TO SUBMUCOSAL TISSUE OF BLADDER PIGS, MMP7, CD44 MAOB 835/4885AKR1B10 1825/4885AKR1B1 1931/4885
US-20060057098-A1 PHOTOREACTIVE POLYSACCHARIDE, PHOTOCROSSLINKED POLYSACCHARIDE PRODUCT AND METHOD OF MAKING SAME AND MEDICAL MATERIALS MADE FROM THE CROSSLINKED POLYSACCHARIDE ALG1, ALG8, CSGALNACT1 MAOB 2372/4885AKR1B10 3227/4885AKR1B1 3958/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.