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Sugi Predict / Targets / CACNG8

CACNG8

Voltage-dependent calcium channel gamma-8 sub · Q8WXS5 · CACNG8 on Sugi Atlas →

15,381 patent compounds predicted against CACNG8, 7,098 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL116362 SCHEMBL116362 0.45 11/20
SCHEMBL1192625 SCHEMBL1192625 0.59 8/20
SCHEMBL2585915 SCHEMBL2585915 0.51 8/20
SCHEMBL980513 SCHEMBL980513 0.60 7/20
SCHEMBL1115539 SCHEMBL1115539 0.47 7/20
SCHEMBL1439986 SCHEMBL1439986 0.47 7/20
SCHEMBL619154 SCHEMBL619154 0.41 7/20
SCHEMBL620978 SCHEMBL620978 0.40 7/20
SCHEMBL621013 SCHEMBL621013 0.40 7/20
SCHEMBL640124 SCHEMBL640124 0.55 6/20
SCHEMBL621555 SCHEMBL621555 0.39 6/20
SCHEMBL617973 SCHEMBL617973 0.38 6/20
SCHEMBL1440205 SCHEMBL1440205 0.53 5/20
SCHEMBL1810921 SCHEMBL1810921 0.51 5/20
SCHEMBL620400 SCHEMBL620400 0.44 5/20
SCHEMBL620595 SCHEMBL620595 0.44 5/20
SCHEMBL619405 SCHEMBL619405 0.43 5/20
SCHEMBL618375 SCHEMBL618375 0.37 5/20
SCHEMBL1163301 SCHEMBL1163301 0.36 5/20
SCHEMBL2340285 SCHEMBL2340285 0.50 4/20

Clinical trials — most relevant to CACNG8 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The Effect of Pregabalin and Etoricoxib on Pain Alone Versus in Combination PHASE4UNKNOWN
Efficacy and Safety of Mirogabalin in Diabetic Peripheral Neuropathic Pain PHASE4RECRUITING
Multimodal Versus Opioid aNalgesia in carDiAc Surgery PHASE4COMPLETED
Role of Intralipid in Management of Organophosphorus Poisoning PHASE2/PHASE3WITHDRAWN
The Re-Prosper HF Study PHASE2/PHASE3COMPLETED
Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia PHASE2/PHASE3COMPLETED
Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Liver Transplant Patients PHASE2WITHDRAWN
Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Trauma Patients PHASE2WITHDRAWN
Population Pharmacokinetic-pharmacodynamic (PK-PD) Modeling of Co-administered Gabapentin in Neuropathic Pain PHASE2COMPLETED
A Phase I/II, First-In-Human Trial to Evaluate the Safety, Tolerability, and Pharmacokinetic Activity to Prevent or Treat Neuropsychiatric Symptoms in Pediatric Subjects With Timothy Syndrome PHASE1/PHASE2NOT_YET_RECRUITING
Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction PHASE2ACTIVE_NOT_RECRUITING
4-Aminopyridine in Episodic Ataxia Type 2 PHASE2WITHDRAWN
The Role of Coenzyme Q10 in the Prophylaxis of Oxaliplatin Induced Peripheral Neuropathy in Patients With Colorectal Cancer PHASE1RECRUITING
Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8 EARLY_PHASE1COMPLETED
Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development nanRECRUITING
Probing the Role of Sodium Channels in Painful Neuropathies nanUNKNOWN
Pharmacogenetics and Cardiovascular Events nanCOMPLETED
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services nanUNKNOWN
Genetic Determinants of Sudden Cardiac Death nanCOMPLETED
Search for Genes Influencing Childhood Absence Epilepsy (CAE) Study nanCOMPLETED
Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases nanUNKNOWN
Factors Affecting Salt Intake in Young Adults nanUNKNOWN
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives nanUNKNOWN
Sodium Channel Splicing in Heart Failure Trial nanCOMPLETED
Genetic Study for Infantile Onset Diabetes Mellitus nanUNKNOWN
Artificial Intelligence for the Prioritization of Genetic Background in Brugada Syndrome nanCOMPLETED
Exploring the Genetics of Neuropathic Pain nanRECRUITING
Neurogenic Mechanisms in Burning Mouth Syndrome nanCOMPLETED
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) in Ischaemic, Inflammatory and Takotsubo Cardiomyopathy (MEMORY) nanCOMPLETED
Early Detection of Cardiomyopathy by Speckle Echo, High Sensitive Troponin and Cardiac Ryanodine Receptors nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a CACNG8 binder may also engage these)

ProteinNameSimilarity
Q8VHW2 — 1.000 Q8VHW2 →
Q8VHW5 — 1.000 Q8VHW5 →
O70141 — 0.949 O70141 →
Q9H3T3 — 0.940 Q9H3T3 →
Q9Z248 — 0.939 Q9Z248 →
O54951 — 0.938 O54951 →
B2RUJ5 — 0.937 B2RUJ5 →
O09112 — 0.936 O09112 →
Q9NWM3 — 0.935 Q9NWM3 →
O75398 — 0.935 O75398 →
A6QL63 — 0.935 A6QL63 →
A4FV57 — 0.935 A4FV57 →
Q6ZMZ0 — 0.935 Q6ZMZ0 →
O75446 — 0.935 O75446 →
AEBP2 Zinc finger protein AEBP2 (Adipocyte enhancer 0.933 landscape →
Q9Y2X7 — 0.933 Q9Y2X7 →
Q6DN14 — 0.933 Q6DN14 →
APBA1 Amyloid-beta A4 precursor protein-binding fam 0.933 landscape →
O35430 — 0.933 O35430 →
O60422 — 0.932 O60422 →
Q6GQW0 — 0.932 Q6GQW0 →
Q6T4P5 — 0.932 Q6T4P5 →
Q8R1S4 — 0.932 Q8R1S4 →
F1LTE0 — 0.932 F1LTE0 →
O42224 — 0.931 O42224 →
Q9P2Q2 — 0.931 Q9P2Q2 →
Q13202 — 0.931 Q13202 →
Q8TBP0 — 0.931 Q8TBP0 →
Q9JJV4 — 0.931 Q9JJV4 →
Q640Q5 — 0.931 Q640Q5 →