SCHEMBL146559

SCHEMBL146559

CCc1ccc(-c2ccccc2)nc1

nearest known ligand 0.65

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.65
RAB9A P51151 4/20 0.65
SMN1; SMN2 Q16637 3/20 0.65
CYP11B1 P15538 12/20 0.59
CYP11B2 P19099 12/20 0.59
CYP3A4 P08684 1/20 0.55
MAPT P10636 1/20 0.49
TP53 P04637 2/20 0.49
NFKB1 P19838 1/20 0.47
MAPK1 P28482 1/20 0.47
NFKB2 Q00653 1/20 0.47
RELA Q04206 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
LDHA P00338 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL28148550 0.98 NPC1 (0.63) NPC1RAB9ASMN1; SMN2CYP11B1CYP11B2
SCHEMBL152870 0.96 NPC1 (0.66) NPC1RAB9ASMN1; SMN2CYP11B1CYP11B2
SCHEMBL27891018 0.91 NPC1 (0.56) NPC1RAB9ASMN1; SMN2CYP11B1CYP11B2
SCHEMBL803150 0.88 RAB9A (0.69) NPC1RAB9ASMN1; SMN2CYP11B1CYP11B2
SCHEMBL22048403 0.87 NPC1 (0.55) NPC1RAB9ASMN1; SMN2CYP11B1CYP11B2
SCHEMBL14879788 0.85 SMN1; SMN2 (0.67) NPC1RAB9ASMN1; SMN2CYP11B1CYP11B2
SCHEMBL15964146 0.85 CYP11B1 (0.56) NPC1RAB9ASMN1; SMN2CYP11B1CYP11B2
SCHEMBL18174631 0.84 RAB9A (0.56) NPC1RAB9ASMN1; SMN2CYP11B1CYP11B2
SCHEMBL31280939 0.83 RAB9A (0.56) NPC1RAB9ASMN1; SMN2MAPTTP53
SCHEMBL7563886 0.83 RAB9A (0.56) NPC1RAB9ASMN1; SMN2MAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250338370-A1 HETEROLEPTIC IRIDIUM COMPLEXES AS DOPANTS UNIVERSAL DISPLAY CORPORATION (US) 2025-10-30 US disclosed
US-12408242-B2 Heteroleptic iridium complexes as dopants UNIVERSAL DISPLAY CORPORATION (US) 2025-09-02 US disclosed
US-20240228478-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. 2024-07-11 US disclosed
US-20240138251-A1 HETEROLEPTIC IRIDIUM COMPLEXES AS DOPANTS UNIVERSAL DISPLAY CORPORATION (US) 2024-04-25 US disclosed
US-11910700-B2 Heteroleptic iridium complexes as dopants UNIVERSAL DISPLAY CORPORATION (US) 2024-02-20 US disclosed
US-20240025934-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2024-01-25 US disclosed
US-20230365582-A1 NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY ON PROSTAGLANDIN E2 RECEPTOR AND USES THEREOF KANAPH THERAPEUTICS INC. (KR) 2023-11-16 US disclosed
US-20230345811-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-10-26 US disclosed
US-20230303601-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-09-28 US disclosed
US-20230287011-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-09-14 US disclosed
US-7759489-B2 Transition metal complex compound and organic electroluminescence device using the compound IDEMITSU KOSAN CO., LTD. (JP) 2010-07-20 US disclosed
US-20100152098-A1 POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF MPEX PHARMACEUTICALS, INC. (US) 2010-06-17 US disclosed
US-20090209556-A1 SOLUBLE GUANYLATE CYCLASE ACTIVATORS MERCK SHARP & DOHME CORP. 2009-08-20 US disclosed
US-20090209556-A1 SOLUBLE GUANYLATE CYCLASE ACTIVATORS MERCK SHARP & DOHME CORP. 2009-08-20 US disclosed
WO-2007119600-A9 CARBAZOLE COMPOUND OTSUKA PHARMA CO LTD (JP) 2008-05-02 WO disclosed
WO-2007119600-A1 CARBAZOLE COMPOUND OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-10-25 WO disclosed
US-20070176540-A1 Transition metal complex compound and organic electroluminescence device using the compound IDEMITSU KOSAN CO., LTD. (JP) 2007-08-02 US disclosed
US-20070179173-A1 Carbostyril compound OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-08-02 US disclosed
US-20070179173-A1 Carbostyril compound OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-08-02 US disclosed
US-20070027321-A1 Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 MERCK SHARP & DOHME CORP. 2007-02-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230303601-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES MGLL, SELENOI, APOL1 NPC1 3111/4885RAB9A 2676/4885SMN1; SMN2 2372/4885
US-12408242-B2 Heteroleptic iridium complexes as dopants JUND, DRD2, DRD1 NPC1 946/4885RAB9A 1245/4885SMN1; SMN2 3320/4885
US-20240025934-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES SSB, RO60, LIFR NPC1 4672/4885RAB9A 560/4885SMN1; SMN2 4178/4885
US-20070176540-A1 Transition metal complex compound and organic electroluminescence device using the compound TMCO1, TIMCC, EMC2 NPC1 3521/4885RAB9A 2555/4885SMN1; SMN2 3908/4885
US-20250338370-A1 HETEROLEPTIC IRIDIUM COMPLEXES AS DOPANTS JUND, DRD2, DRD1 NPC1 946/4885RAB9A 1245/4885SMN1; SMN2 3320/4885
US-20230287011-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD2, OXGR1, OCIAD1 NPC1 3285/4885RAB9A 1311/4885SMN1; SMN2 3545/4885
US-20100152098-A1 POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF ABCB11, ABCB1, SLC47A1 NPC1 124/4885RAB9A 495/4885SMN1; SMN2 4857/4885
US-20070179173-A1 Carbostyril compound GTF2F1, F3, GTF2F2 NPC1 2922/4885RAB9A 2273/4885SMN1; SMN2 3084/4885
US-20230365582-A1 NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY ON PROSTAGLANDIN E2 RECEPTOR AND USES THEREOF PTGER1, PTGIR, PTGDR2 NPC1 2415/4885RAB9A 3159/4885SMN1; SMN2 4658/4885
US-20070027321-A1 Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 GRM5, GRIK5, GRM1 NPC1 3553/4885RAB9A 1672/4885SMN1; SMN2 2910/4885
US-20090209556-A1 SOLUBLE GUANYLATE CYCLASE ACTIVATORS GUCY1B1, GUCY1A2, GUCY1A1 NPC1 2757/4885RAB9A 1349/4885SMN1; SMN2 1171/4885
US-20240138251-A1 HETEROLEPTIC IRIDIUM COMPLEXES AS DOPANTS JUND, DRD2, DRD1 NPC1 946/4885RAB9A 1245/4885SMN1; SMN2 3320/4885
US-20240228478-A1 COMPOUNDS AND METHODS OF USE F12, C1R, ABCG2 NPC1 39/4885RAB9A 320/4885SMN1; SMN2 1943/4885
US-20230345811-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OPRD1, L1CAM, OPRM1 NPC1 1706/4885RAB9A 1045/4885SMN1; SMN2 2191/4885
US-11910700-B2 Heteroleptic iridium complexes as dopants JUND, DRD2, DRD1 NPC1 946/4885RAB9A 1245/4885SMN1; SMN2 3320/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.