SCHEMBL381612

SCHEMBL381612

C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CCCC(O)(O)[C@]4(C)[C@H]3CC[C@]12C

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPBAR1 Q8TDU6 4/20 0.74
HSD17B10 Q99714 3/20 0.74
TDP1 Q9NUW8 3/20 0.74
EPHA2 P29317 3/20 0.74
AKR1B10 O60218 2/20 0.74
AKR1B1 P15121 2/20 0.74
LMNA P02545 2/20 0.74
EFNA1 P20827 1/20 0.74
PSEN1 P49768 1/20 0.74
PSEN2 P49810 1/20 0.74
APH1B Q8WW43 1/20 0.74
NCSTN Q92542 1/20 0.74
APH1A Q96BI3 1/20 0.74
PSENEN Q9NZ42 1/20 0.74
MEN1 O00255 1/20 0.74
KMT2A Q03164 1/20 0.74
VDR P11473 5/20 0.66
CASP7 P55210 3/20 0.66
TP53 P04637 2/20 0.66
MAPK1 P28482 2/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4751618 1.00 GPBAR1 (0.74) GPBAR1HSD17B10TDP1EPHA2AKR1B10
SCHEMBL10906860 1.00 GPBAR1 (0.74) GPBAR1HSD17B10TDP1EPHA2AKR1B10
SCHEMBL11573739 0.91 GPBAR1 (0.60) GPBAR1HSD17B10TDP1EPHA2AKR1B10
SCHEMBL7146262 0.90 GPBAR1 (0.70) GPBAR1HSD17B10TDP1EPHA2AKR1B10
SCHEMBL1492095 0.88 GPBAR1 (0.67) GPBAR1HSD17B10TDP1EPHA2AKR1B10
Meglumine SCHEMBL23671098 0.87 GPBAR1 (0.57) GPBAR1HSD17B10TDP1EPHA2AKR1B10
SCHEMBL1618569 0.87 GPBAR1 (0.54) GPBAR1HSD17B10TDP1EPHA2AKR1B10
SCHEMBL19064920 0.87 GPBAR1 (0.54) GPBAR1HSD17B10TDP1EPHA2AKR1B10
SCHEMBL11340170 0.86 GPBAR1 (0.56) GPBAR1HSD17B10TDP1EPHA2AKR1B10
SCHEMBL977813 0.85 VDR (0.69) GPBAR1HSD17B10TDP1EPHA2AKR1B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3538158-B1 TREATMENT FOR FIBROSIS GALMED RES AND DEVELOPMENT LTD (IL) 2023-11-01 EP claimed
EP-3538159-B1 INHIBITION OF FIBROSIS IN NON-ALCOHOLIC FATTY LIVER DISEASE PATIENTS GALMED RES AND DEVELOPMENT LTD (IL) 2023-04-05 EP claimed
EP-4133266-A1 IMPROVED METHODS FOR EVALUATING LIVER FUNCTION Hepquant, LLC (US) 2023-02-15 EP claimed
US-20220362263-A1 TREATMENT FOR FIBROSIS AND INHIBITION OF FIBROSIS GALMED RESEARCH AND DEVELOPMENT LTD (IL) 2022-11-17 US claimed
US-11197870-B2 Treatment for hepatic fibrosis GALMED RESEARCH AND DEVELOPMENT LTD (IL) 2021-12-14 US claimed
EP-3875596-A1 METHOD FOR HYDROXYLATION OF STEROIDS Pharmazell GmbH (DE) 2021-09-08 EP claimed
US-20210169901-A1 TREATMENT FOR MODULATING GUT MICROBIOTA GALMED RESEARCH AND DEVELOPMENT LTD. (IL) 2021-06-10 US claimed
EP-3538159-A1 INHIBITION OF FIBROSIS IN NON-ALCOHOLIC FATTY LIVER DISEASE PATIENTS Galmed Research and Development Ltd. (IL) 2019-09-18 EP claimed
US-20190275061-A1 INHIBITION OF FIBROSIS IN NON ALCOHOL FATTY LIVER DISEASE PATIENTS GALMED RESEARCH AND DEVELOPMENT LTD (IL) 2019-09-12 US claimed
US-20190175619-A1 TREATMENT OF FIBROSIS, AND INHIBITION OF FIBROSIS IN NON-ALCOHOLIC FATTY LIVER DISEASE PATIENTS GALMED RESEARCH AND DEVELOPMENT LTD. (IL) 2019-06-13 US claimed
WO-2018087600-A1 INHIBITION OF FIBROSIS IN NON-ALCOHOLIC FATTY LIVER DISEASE PATIENTS GALMED RESEARCH AND DEVELOPMENT LTD. (IL) 2018-05-17 WO claimed
WO-2018051180-A1 TREATMENT FOR DIASTOLIC DYSFUNCTION GALMED RESEARCH AND DEVELOPMENT LTD. (IL) 2018-03-22 WO claimed
US-20170196891-A1 FATTY ACID BILE ACID CONJUGATES FOR TREATMENT OF LIPODYSTROPHY GALMED RESEARCH AND DEVELOPMENT LTD. (IL) 2017-07-13 US claimed
US-20090149537-A1 Use of Bile Acid or Bile Salt Fatty Acid Conjugates GALMED INTERNATIONAL LIMITED (MT) 2009-06-11 US claimed
JP-7017867-A None JP disclosed
EP-3645548-B1 METHODS FOR PREPARING BILE ACIDS MEDYTOX INC (KR) 2023-11-29 EP disclosed
EP-3538158-B1 TREATMENT FOR FIBROSIS GALMED RES AND DEVELOPMENT LTD (IL) 2023-11-01 EP disclosed
EP-0168229-B1 PHARMACEUTICAL ANTIFUNGAL COMPOSITION BTG INTERNATIONAL LIMITED (GB) 1993-09-15 EP disclosed
US-4681876-A Antifungal utility of bile acids NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1987-07-21 US disclosed
EP-0168229-A2 Pharmaceutical antifungal composition BTG INTERNATIONAL LIMITED (GB) 1986-01-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190275061-A1 INHIBITION OF FIBROSIS IN NON ALCOHOL FATTY LIVER DISEASE PATIENTS ACACA, LIPC, CYP46A1 GPBAR1 165/4885HSD17B10 78/4885TDP1 4796/4885
US-20210169901-A1 TREATMENT FOR MODULATING GUT MICROBIOTA NR1H4, SLC10A2, FABP2 GPBAR1 4/4885HSD17B10 196/4885TDP1 4510/4885
US-20220362263-A1 TREATMENT FOR FIBROSIS AND INHIBITION OF FIBROSIS CYP46A1, LPCAT3, NR1H4 GPBAR1 142/4885HSD17B10 240/4885TDP1 4823/4885
US-11197870-B2 Treatment for hepatic fibrosis NR1H4, ACACA, LIPC GPBAR1 56/4885HSD17B10 131/4885TDP1 4834/4885
US-20170196891-A1 FATTY ACID BILE ACID CONJUGATES FOR TREATMENT OF LIPODYSTROPHY CYP27A1, LIPC, SLC27A1 GPBAR1 93/4885HSD17B10 57/4885TDP1 3289/4885
US-20190175619-A1 TREATMENT OF FIBROSIS, AND INHIBITION OF FIBROSIS IN NON-ALCOHOLIC FATTY LIVER DISEASE PATIENTS LIPC, SLC10A1, ACACA GPBAR1 169/4885HSD17B10 70/4885TDP1 4782/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.