SCHEMBL341755

SCHEMBL341755

NCC(C[N+](=O)[O-])c1ccc(Cl)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GABBR2 O75899 6/20 0.56
▸ GABBR1 Q9UBS5 6/20 0.56
▸ LMNA P02545 4/20 0.53
▸ CYP2C9 P11712 2/20 0.53
▸ CYP1A2 P05177 2/20 0.53
▸ THRB P10828 2/20 0.53
▸ CYP3A4 P08684 1/20 0.53
▸ ADORA3 P0DMS8 1/20 0.53
▸ NFKB1 P19838 1/20 0.53
▸ DRD3 P35462 1/20 0.53
▸ BLM P54132 1/20 0.53
▸ CYP2D6 P10635 1/20 0.53
▸ CYP2C19 P33261 1/20 0.53
▸ MEN1 O00255 1/20 0.53
▸ TSHR P16473 1/20 0.53
▸ KMT2A Q03164 1/20 0.53
▸ MAPT P10636 4/20 0.51
▸ SMN1; SMN2 Q16637 2/20 0.51
▸ PMP22 Q01453 1/20 0.51
▸ NPSR1 Q6W5P4 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15389394 0.89 ALDH1A1 (0.48) GABBR2GABBR1LMNACYP2C9CYP1A2
SCHEMBL11148252 0.81 GABBR2 (0.52) GABBR2GABBR1MEN1KMT2AMAPT
SCHEMBL22988782 0.79 ALDH1A1 (0.42) GABBR2GABBR1LMNACYP2C9CYP1A2
SCHEMBL21216019 0.79 ALDH1A1 (0.42) GABBR2GABBR1LMNACYP2C9CYP1A2
SCHEMBL27725205 0.79 ALDH1A1 (0.42) GABBR2GABBR1LMNACYP2C9CYP1A2
SCHEMBL27725190 0.78 GABBR2 (0.61) GABBR2GABBR1LMNACYP2C9CYP1A2
SCHEMBL21686411 0.78 GABBR2 (0.61) GABBR2GABBR1LMNACYP2C9CYP1A2
SCHEMBL9988481 0.78 GABBR2 (0.61) GABBR2GABBR1LMNACYP2C9CYP1A2
SCHEMBL10507284 0.78 GABBR2 (0.64) GABBR2GABBR1LMNACYP2C9CYP1A2
SCHEMBL27165024 0.77 GABBR2 (0.44) GABBR2GABBR1LMNACYP2C9CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011113904-A1 MEDICAMENTS FOR THE PREVENTION AND TREATMENT OF A DISEASE ASSOCIATED WITH RETINAL GANGLION CELL DEGENERATION INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2011-09-22 — — WO claimed
US-20090252786-A1 Use of a Biologically Active Blood Serum for the Treatment of a Disorder Characterized in a Reduced Function of a GABA Receptor OWEN HOLDING LTD. (GB) 2009-10-08 — — US claimed
EP-2106799-A1 Use of a biologically active blood serum for the treatment of a disorder characterized in a reduced function of a GABA receptor OWEN Holding LTD (GB) 2009-10-07 — — EP claimed
US-20060241134-A1 Pharmaceutical combinations of a proton pump inhibitor and a compound which modifies gastrointestinal motility ALTANA PHARMA GA (DE) 2006-10-26 — — US claimed
US-20060089335-A1 Compositions and methods for enhancing cognitive function and synaptic plasticity NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2006-04-27 — — US claimed
WO-2005037215-A2 COMPOSITIONS AND METHODS FOR ENHANCING COGNITIVE FUNCTION AND SYNAPTIC PLASTICITY MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2005-04-28 — — WO claimed
EP-0936906-B1 REFLUX INHIBITORS ASTRAZENECA AB (SE) 2003-09-10 — — EP claimed
WO-1996011680-A2 USE OF GABA AGONISTS IN THE TREATMENT OF EMESIS GLAXO GROUP LIMITED (GB) 1996-04-25 — — WO claimed
US-12560607-B2 Recombinant viruses, insect cells and their uses in viral detection and vaccination ACADEMIA SINICA (TW) 2026-02-24 — — US disclosed
CN-118546565-A Fluorocarbon ink for solar panel, preparation method and use method of fluorocarbon ink 昆山大世界油墨涂料有限公司 2024-08-27 — — CN disclosed
US-20240271001-A1 ANTI-GLARE FILM BENQ MATERIALS CORPORATION (TW) 2024-08-15 — — US disclosed
CN-110628729-B Baculovirus and composition for detecting and preventing porcine epidemic diarrhea virus infection 周美吟 2024-05-28 — — CN disclosed
US-20240123219-A1 STIMULATION DESIGN FOR NEUROMODULATION ADVANCED NEUROMODULATION SYSTEMS, INC. 2024-04-18 — — US disclosed
US-11883648-B2 Stimulation design for neuromodulation ADVANCED NEUROMODULATION SYSTEMS, INC. (US) 2024-01-30 — — US disclosed
WO-2002096404-A1 METHOD OF TREATING GASTROESOPHAGEAL REFLUX DISEASE AND NOCTURNAL ACID BREAKTHROUGH DEPOMED DEVELOPMENT LTD (GB) 2002-12-05 — — WO disclosed
US-6117908-A Use of GABAB receptor agonists as reflux inhibitors ASTRA AKTIEBOLAG (SE) 2000-09-12 — — US disclosed
CN-1237105-A Reflux inhibitors ASTRA AB (SE) 1999-12-01 — — CN disclosed
EP-0936906-A1 REFLUX INHIBITORS Astra Aktiebolag (SE) 1999-08-25 — — EP disclosed
WO-1998011885-A1 REFLUX INHIBITORS ASTRA AKTIEBOLAG (SE) 1998-03-26 — — WO disclosed
WO-1996011680-A2 USE OF GABA AGONISTS IN THE TREATMENT OF EMESIS GLAXO GROUP LIMITED (GB) 1996-04-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060089335-A1 Compositions and methods for enhancing cognitive function and synaptic plasticity GRIN2B, CACNA1B, GRIN2A GABBR2 63/4885GABBR1 54/4885LMNA 4077/4885
US-12560607-B2 Recombinant viruses, insect cells and their uses in viral detection and vaccination HSPB1, HSPA2, HSPBP1 GABBR2 3453/4885GABBR1 3847/4885LMNA 1323/4885
US-20090252786-A1 Use of a Biologically Active Blood Serum for the Treatment of a Disorder Characterized in a Reduced Function of a GABA Receptor GABBR1, GABBR2, GABRA2 GABBR2 2/4885GABBR1 1/4885LMNA 2397/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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