Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRB7 | Q14451 | 2/20 | 0.70 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15748405 | 0.76 | GRB7 (0.85) | GRB7ITGB3ITGA2BKEAP1 | |
| SCHEMBL15748376 | 0.73 | GRB7 (0.72) | GRB7ITGB3ITGA2B | |
| SCHEMBL31060478 | 0.73 | ITGB3 (0.56) | GRB7ITGB3ITGA2B | |
| SCHEMBL22872704 | 0.69 | ITGB3 (0.59) | ITGB3ITGA2B | |
| SCHEMBL22342240 | 0.69 | KEAP1 (0.63) | KEAP1 | |
| SCHEMBL13573536 | 0.68 | ITGB3 (0.51) | GRB7ITGB3ITGA2B | |
| SCHEMBL22342263 | 0.68 | KEAP1 (0.63) | ITGB3ITGA2BKEAP1 | |
| SCHEMBL16576430 | 0.68 | OXTR (0.51) | GRB7ITGB3ITGA2B | |
| SCHEMBL16135323 | 0.68 | ITGB3 (0.54) | ITGB3ITGA2B | |
| SCHEMBL30389411 | 0.68 | FLT1 (0.49) | GRB7OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014078889-A1 | IMPROVED INHIBITORS OF GRB7 | MONASH UNIVERSITY (AU) | 2014-05-30 | — | — | WO | disclosed |