Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Evans Blue Free Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 6/20 | 0.77 |
| ▸ | ENPP2 | Q13822 | 3/20 | 1.00 |
| ▸ | HSPD1 | P10809 | 2/20 | 1.00 |
| ▸ | HSPE1 | P61604 | 2/20 | 1.00 |
| ▸ | TST | Q16762 | 2/20 | 1.00 |
| ▸ | PTPN1 | P18031 | 2/20 | 1.00 |
| ▸ | ALB | P02768 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.77 |
| ▸ | RECQL | P46063 | 5/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.77 |
| ▸ | HPGD | P15428 | 4/20 | 0.77 |
| ▸ | MEN1 | O00255 | 4/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.77 |
| ▸ | APEX1 | P27695 | 2/20 | 0.77 |
| ▸ | USP2 | O75604 | 2/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Evans Blue Free Acid SCHEMBL29377040 | 1.00 | ENPP2 (1.00) | ENPP2HSPD1HSPE1TSTPTPN1 | |
| Evans Blue Free Acid SCHEMBL30392230 | 1.00 | ENPP2 (1.00) | ENPP2HSPD1HSPE1TSTPTPN1 | |
| Evans Blue Free Acid SCHEMBL29601874 | 1.00 | ENPP2 (1.00) | ENPP2HSPD1HSPE1TSTPTPN1 | |
| Evans Blue Free Acid SCHEMBL29381789 | 1.00 | ENPP2 (1.00) | ENPP2HSPD1HSPE1TSTPTPN1 | |
| Evans Blue Free Acid SCHEMBL2437648 | 1.00 | ENPP2 (1.00) | ENPP2HSPD1HSPE1TSTPTPN1 | |
| Evans Blue Free Acid SCHEMBL29609615 | 0.87 | MEN1 (0.98) | ENPP2HSPD1HSPE1TSTPTPN1 | |
| Chicago Sky Blue SCHEMBL93506 | 0.87 | THRB (1.00) | ENPP2HSPD1HSPE1TSTPTPN1 | |
| Chicago Sky Blue SCHEMBL29358365 | 0.87 | THRB (1.00) | ENPP2HSPD1HSPE1TSTPTPN1 | |
| Chicago Sky Blue SCHEMBL29401288 | 0.87 | THRB (1.00) | ENPP2HSPD1HSPE1TSTPTPN1 | |
| Chicago Sky Blue SCHEMBL30201536 | 0.87 | THRB (1.00) | ENPP2HSPD1HSPE1TSTPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 25071 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115985521-B | Qingkailing injection anaphylactic reaction detection model | GUANGZHOU BAIYUN SHAN MING XING PHARMACEUTICAL Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| US-20260139023-A1 | NOVEL IRISIN PEPTIDES AND METHODS OF USE THEREOF | DANA FARBER CANCER INST INC (US) | 2026-05-21 | — | — | US | claimed |
| WO-2026088112-A1 | COMBINATION THERAPIES WITH AR-DEGRADING AGENTS AND PSMA-TARGETING RADIOLIGANDS | NOVARTIS AG (CH) | 2026-04-30 | — | — | WO | claimed |
| US-12539281-B2 | Arterial application of low dose ethyl alcohol enables blood-brain barrier (BBB) transient opening | WANG WEIJUN (US) | 2026-02-03 | — | — | US | claimed |
| EP-4227300-B1 | TRUNCATED EVANS BLUE MODIFIED FIBROBLAST ACTIVATION PROTEIN INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | YANTAI LANNACHENG BIOTECHNOLOGY CO LTD (CN) | 2026-01-28 | — | — | EP | claimed |
| US-20250382329-A1 | INTERMEDIATE USED FOR FAPI SYNTHESIS, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | YANTAI LANNACHENG BIOTECHNOLOGY CO LTD (CN) | 2025-12-18 | — | — | US | claimed |
| EP-4652180-A2 | PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR | Janssen Pharmaceutica NV (BE) | 2025-11-26 | — | — | EP | claimed |
| EP-4651876-A1 | TARGETED THERANOSTIC AGENTS FOR IMAGING AND TREATING CANCER | The Board of Regents of the University of Texas System (US) | 2025-11-26 | — | — | EP | claimed |
| EP-4649138-A1 | COMBINATION OF COMPOUNDS FOR DEVELOPING IN VITRO MODELS OF THE BLOOD-BRAIN BARRIER | Hun-Ren Szegedi Biológiai Kutatóközpont (HU) | 2025-11-19 | — | — | EP | claimed |
| US-20250345288-A1 | Arterial Application of Low Dose Ethyl Alcohol Enables Blood-Brain Barrier (BBB) Transient Opening | WANG WEIJUN (US) | 2025-11-13 | — | — | US | claimed |
| US-4880788-A | Method for preventing and treating thrombosis | BAYLOR COLLEGE OF MEDICINE (US) | 1989-11-14 | — | — | US | claimed |
| US-4863875-A | Dye labelled antibodies as reagents for use in immunoassay systems | GIA RESEARCH COMPANY, L.P. (US) | 1989-09-05 | — | — | US | claimed |
| WO-1989004166-A1 | METHOD FOR PREVENTING AND TREATING OF THROMBOSIS | BMRT, LTD. (US) | 1989-05-18 | — | — | WO | claimed |
| US-4799479-A | Method and apparatus for angioplasty | THE BETH ISRAEL HOSPITAL ASSOCIATION (US) | 1989-01-24 | — | — | US | claimed |
| EP-0287581-A1 | PROCESS FOR MANUFACTURING A RECEPTOR PREPARATION FOR A RADIO-RECEPTOR ASSAY AND KIT-ORIENTED RADIO-RECEPTOR ASSAY IN ACCORDANCE WITH THE PROCESS. | ANAWA LAB AG (CH) | 1988-10-26 | — | — | EP | claimed |
| WO-1988007532-A1 | 2',3' DIDEOXYRIBOFURANOXIDE DERIVATIVES | NYCOMED A.S. (NO) | 1988-10-06 | — | — | WO | claimed |
| WO-1988002861-A1 | PROCESS FOR MANUFACTURING A RECEPTOR PREPARATION FOR A RADIO-RECEPTOR ASSAY AND KIT-ORIENTED RADIO-RECEPTOR ASSAY IN ACCORDANCE WITH THE PROCESS | ANAWA LABORATORIEN AG (CH) | 1988-04-21 | — | — | WO | claimed |
| EP-0210417-A1 | A method and an apparatus for determining blood components | RADIOMETER A/S (DK) | 1987-02-04 | — | — | EP | claimed |
| EP-0182689-A2 | Apparatus for angioplasty | THE BETH ISRAEL HOSPITAL ASSOCIATION (US) | 1986-05-28 | — | — | EP | claimed |
| EP-0072319-B1 | COLOURED TOXOPLASMS IN A STABLE SUSPENSION AND THEIR APPLICATION TO THE DIAGNOSIS OF TOXOPLASMOSIS | LABORATOIRES BIOTROL S.A. (FR) | 1986-01-15 | — | — | EP | claimed |