NDUFS1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Auraptene (SCHEMBL2535029)	1.00	5/20
Auraptene (SCHEMBL2535034)	1.00	5/20
SCHEMBL8491443	0.56	4/20
SCHEMBL8489900	0.52	4/20
SCHEMBL8489907	0.52	4/20
SCHEMBL8492838	0.52	4/20
SCHEMBL8492845	0.52	4/20
SCHEMBL8489902	0.51	4/20
SCHEMBL8489908	0.51	4/20
SCHEMBL8491154	0.51	4/20
SCHEMBL8491160	0.51	4/20
SCHEMBL8491619	0.50	4/20
SCHEMBL8491624	0.50	4/20
SCHEMBL8491634	0.50	4/20
SCHEMBL8494171	0.50	4/20
SCHEMBL8494175	0.50	4/20
SCHEMBL8494177	0.50	4/20
7-Prenyloxycoumarin (SCHEMBL4898255)	0.79	3/20
SCHEMBL712741	0.57	3/20
Geiparvarin (SCHEMBL2532495)	0.56	3/20

Clinical trials — most relevant to NDUFS1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease	PHASE3	COMPLETED
Effect of Montelukast Versus Co Enzyme in Sepsis	PHASE2/PHASE3	COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
Deoxynucleosides Pyrimidines as Treatment for Mitochondrial Depletion Syndrome	PHASE2	RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome	PHASE1/PHASE2	COMPLETED
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease	PHASE2	COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
The Natural History of Mitochondrial Diseases	nan	RECRUITING
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
Mitoquines in COPD	nan	UNKNOWN
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Development of a New Technique for Quantifying Mitochondrial DNA in Single Muscle Fibers	nan	NOT_YET_RECRUITING
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip	nan	COMPLETED
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection	nan	COMPLETED
The Genetics of Diabetes in Southern California Chinese Americans	nan	WITHDRAWN
Assessment of Follicular Fluid Level of Coenzyme Q10 in Women Undergoing ICSI	nan	UNKNOWN
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants	nan	RECRUITING
The Impact of Mitochondrial Dysfunction on Human Bone Cell Metabolism and Remodelling	nan	ACTIVE_NOT_RECRUITING
Cardiac Mitochondrial Function in Explanted Human Hearts	nan	UNKNOWN
Human Mitochondrial Stress-driven Obesity Resistance	nan	COMPLETED
EPI-743 for Mitochondrial Respiratory Chain Diseases	nan	NO_LONGER_AVAILABLE
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy	nan	RECRUITING
Diagnostic Odyssey Survey 2	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NDUFS1 binder may also engage these)

Protein	Name	Similarity
P0CB67	—	1.000	P0CB67 →
Q0MQG2	—	1.000	Q0MQG2 →
Q0MQG1	—	1.000	Q0MQG1 →
P15690	—	1.000	P15690 →
Q66HF1	—	1.000	Q66HF1 →
P0CB68	—	1.000	P0CB68 →
Q91VD9	—	1.000	Q91VD9 →
Q4R6K9	—	1.000	Q4R6K9 →
Q9FGI6	—	0.967	Q9FGI6 →
Q43644	—	0.967	Q43644 →
P32296	—	0.962	P32296 →
Q6NYG8	—	0.960	Q6NYG8 →
Q27601	—	0.959	Q27601 →
Q96480	—	0.959	Q96480 →
O04226	—	0.959	O04226 →
Q29554	—	0.958	Q29554 →
O04015	—	0.958	O04015 →
O65361	—	0.955	O65361 →
O89000	—	0.955	O89000 →
HMBS	Porphobilinogen deaminase	0.955	landscape →
Q64428	—	0.955	Q64428 →
Q6AV34	—	0.955	Q6AV34 →
Q8BMS1	—	0.955	Q8BMS1 →
P19356	—	0.954	P19356 →
HADHA	Trifunctional enzyme subunit alpha, mitochondrial	0.954	landscape →
P54887	—	0.953	P54887 →
Q28943	—	0.953	Q28943 →
Q94511	—	0.953	Q94511 →
A7M6E8	—	0.953	A7M6E8 →
Q8CHR6	—	0.953	Q8CHR6 →