SCHEMBL2572179

SCHEMBL2572179

O=C(Nc1cc(-c2ccccc2)ccc1C(=O)O)c1ccc(-n2ccnc2)cc1O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 1/20 0.50
MEN1 O00255 1/20 0.49
ALOX15 P16050 1/20 0.49
TSHR P16473 1/20 0.49
KMT2A Q03164 1/20 0.49
PORCN Q9H237 7/20 0.48
ACLY P53396 2/20 0.47
ADH5 P11766 1/20 0.47
CYP3A4 P08684 2/20 0.46
CYP2D6 P10635 1/20 0.46
HDAC1 Q13547 3/20 0.46
PTPN11 Q06124 1/20 0.45
KDM4E B2RXH2 1/20 0.44
ALDH1A1 P00352 1/20 0.44
POLB P06746 1/20 0.44
HPGD P15428 1/20 0.44
MAPK1 P28482 1/20 0.44
HSD17B10 Q99714 1/20 0.44
HNF4A P41235 1/20 0.44
ACMSD Q8TDX5 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1316097 0.99 DHODH (0.49) DHODHMEN1ALOX15TSHRKMT2A
SCHEMBL12117692 0.93 DHODH (0.49) DHODHMEN1ALOX15TSHRKMT2A
Hydrochloric Acid SCHEMBL1316243 0.92 DHODH (0.48) DHODHMEN1ALOX15TSHRKMT2A
SCHEMBL1317353 0.87 CYP3A4 (0.45) DHODHMEN1ALOX15TSHRKMT2A
SCHEMBL13205877 0.82 PORCN (0.48) DHODHMEN1ALOX15TSHRKMT2A
SCHEMBL1316456 0.82 ACLY (0.50) ACLYHDAC1HNF4AACMSD
SCHEMBL13205878 0.81 PORCN (0.47) DHODHMEN1ALOX15TSHRKMT2A
SCHEMBL1320352 0.80 ACMSD (0.68) DHODHMEN1KMT2AACLYHDAC1
SCHEMBL12117697 0.80 CYP3A4 (0.44) DHODHMEN1ALOX15TSHRKMT2A
SCHEMBL1317748 0.80 HDAC1 (0.60) DHODHACLYHDAC1HNF4AACMSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 EP disclosed
WO-2010087430-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF 富山化学工業株式会社 (JP) 2010-08-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 DHODH 2784/4885MEN1 3020/4885ALOX15 582/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.