RBCK1

RanBP-type and C3HC4-type zinc finger-contain · Q9BYM8 · RBCK1 on Sugi Atlas →

63 patent compounds predicted against RBCK1, 47 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Gliotoxin (SCHEMBL54420)	1.00	1/20
Gliotoxin (SCHEMBL4294337)	1.00	1/20
Gliotoxin (SCHEMBL9667270)	1.00	1/20
Gliotoxin (SCHEMBL12018743)	1.00	1/20
Gliotoxin (SCHEMBL12149513)	1.00	1/20
Gliotoxin (SCHEMBL12618354)	1.00	1/20
Gliotoxin (SCHEMBL13341245)	1.00	1/20
Gliotoxin (SCHEMBL14514067)	1.00	1/20
Gliotoxin (SCHEMBL14579856)	1.00	1/20
Gliotoxin (SCHEMBL14986985)	1.00	1/20
Gliotoxin (SCHEMBL20199940)	1.00	1/20
Gliotoxin G (SCHEMBL30567451)	0.88	1/20
SCHEMBL12901998	0.84	1/20
SCHEMBL14021819	0.84	1/20
SCHEMBL25722212	0.82	1/20
Gliotoxin (SCHEMBL6934245)	0.73	1/20
Gliotoxin (SCHEMBL4735750)	0.71	1/20
Gliotoxin (SCHEMBL14332623)	0.71	1/20
SCHEMBL18652980	0.66	1/20
SCHEMBL17971336	0.64	1/20

Clinical trials — most relevant to RBCK1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
Phase II Study of Vandetanib in Individuals With Kidney Cancer	PHASE2	COMPLETED
Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma	PHASE2	WITHDRAWN
Treatment With Azacitidine of Recurrent Gliomas With IDH1/2 Mutation	PHASE2	UNKNOWN
Mobilization and Collection of Peripheral Blood Stem Cells in Patients With Fanconi Anemia Using G-CSF and AMD3100	PHASE1/PHASE2	COMPLETED
Human Leukocyte Antigen (HLA) - A*2402 Restricted Peptide Vaccine Therapy in Patients With Advanced Esophageal Cancer	PHASE1	COMPLETED
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck	PHASE1	COMPLETED
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia	nan	UNKNOWN
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Tecfidera Diffusion Tensor Imaging	nan	COMPLETED
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Family Study of Head and Neck Cancers in Taiwan	nan	COMPLETED
Family Blood Pressure Program - GenNet Network	nan	COMPLETED
Amplification of Zinc Finger Protein 217 Gene in Multiple Myeloma	nan	UNKNOWN
DCLK1 as a Marker/Indicator of Stem Cell Response in Barrett's Esophagus/Esophageal Adenocarcinoma	nan	COMPLETED
Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics	nan	UNKNOWN
ADAPT: Efficacy of a Dietary Supplement During and After Exercise	nan	COMPLETED
Muscle Wasting in Cancer (MWIC)	nan	COMPLETED
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population	nan	COMPLETED
Pharmacogenomics of Interferon and Ribavirin Treatment in Patients With Chronic Hepatitis C Virus Infection	nan	UNKNOWN
Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science	nan	RECRUITING
PCD New Gene Discovery	nan	COMPLETED
The Role of RING Ubiquitin Ligases in Biologic and Oncologic Processes in Tissues of Mesenchymal Origin	nan	UNKNOWN
Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis	nan	COMPLETED
Value of MicroRNA30a in Philadelphia Positive Leukemic Patients	nan	UNKNOWN
Detection of Krupple Like Factor -1(KLF1/ EKLF) DNA Mutations in Beta Thalassemia Patients	nan	NOT_YET_RECRUITING
New Genes Involved in Molecular Etiology of Rett Syndrome Through DNA Microarray Comparative Genomic Hybridization	nan	COMPLETED
Hemochromatosis and Iron Overload Screening Study (HEIRS)	nan	COMPLETED
Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants.	nan	UNKNOWN
Rheo-Erythrocrine Dysfunction as a Biomarker for RIC Treatment in Acute Ischemic Stroke	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a RBCK1 binder may also engage these)

Protein	Name	Similarity
Q9WUB0	—	1.000	Q9WUB0 →
Q62921	—	1.000	Q62921 →
RNF31	E3 ubiquitin-protein ligase RNF31	0.971	landscape →
MAP4K2	Mitogen-activated protein kinase kinase kinase kinase 2	0.968	landscape →
E6ZIJ1	—	0.967	E6ZIJ1 →
Q924T7	—	0.966	Q924T7 →
P70268	—	0.964	P70268 →
Q61161	—	0.964	Q61161 →
PKN1	Serine/threonine-protein kinase N1	0.963	landscape →
A1A4I4	—	0.963	A1A4I4 →
Q13474	—	0.963	Q13474 →
Q496Y0	—	0.962	Q496Y0 →
Q6ZT62	—	0.961	Q6ZT62 →
Q8K1B8	—	0.961	Q8K1B8 →
Q5F3B2	—	0.961	Q5F3B2 →
IKBKE	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0.960	landscape →
Q8BY35	—	0.960	Q8BY35 →
EIF2B5	Translation initiation factor eIF2B subunit epsilon	0.960	landscape →
P47823	—	0.960	P47823 →
O60232	—	0.960	O60232 →
O35465	—	0.960	O35465 →
Q8ND23	—	0.960	Q8ND23 →
Q6GMV2	—	0.959	Q6GMV2 →
Q5NVK5	—	0.959	Q5NVK5 →
Q86UX7	—	0.959	Q86UX7 →
Q3B7U9	—	0.959	Q3B7U9 →
O60784	—	0.959	O60784 →
Q3TYX3	—	0.959	Q3TYX3 →
A5PK19	—	0.959	A5PK19 →
Q05AA6	—	0.959	Q05AA6 →