SCHEMBL76846

SCHEMBL76846

NC[C@H]1CN(c2ccc(N3CCOCC3)c(F)c2)C(=O)O1

nearest known ligand 0.69

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOB P27338 13/20 0.69
MAOA P21397 6/20 0.69
PTGS1 P23219 2/20 0.69
SDHA P31040 2/20 0.69
LMNA P02545 1/20 0.69
CALML3 P27482 1/20 0.69
F10 P00742 4/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1336215 1.00 MAOB (0.69) MAOBMAOAPTGS1SDHALMNA
SCHEMBL29439547 1.00 MAOB (0.69) MAOBMAOAPTGS1SDHALMNA
SCHEMBL5513933 1.00 MAOB (0.69) MAOBMAOAPTGS1SDHALMNA
Acetic Acid SCHEMBL1338391 0.94 MAOB (0.74) MAOBMAOAPTGS1SDHALMNA
Acetic Acid SCHEMBL1338393 0.94 MAOB (0.74) MAOBMAOAPTGS1SDHALMNA
SCHEMBL3523989 0.91 F10 (0.59) MAOBMAOAPTGS1SDHALMNA
SCHEMBL3523994 0.91 F10 (0.59) MAOBMAOAPTGS1SDHALMNA
SCHEMBL3525075 0.89 F10 (0.58) MAOBMAOAPTGS1SDHALMNA
SCHEMBL12176864 0.89 MAOB (0.70) MAOBMAOAPTGS1SDHALMNA
SCHEMBL13404010 0.89 F10 (0.58) MAOBMAOAPTGS1SDHALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 337 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114505036-A Method and equipment for preparing linezolid 程竹隐 2022-05-17 CN claimed
EP-2902386-B1 A crystalline form of linezolid SYMED LABS LTD (IN) 2020-04-08 EP claimed
CN-110934880-A Compositions containing mixtures of phenyl oxazolidinone derivatives and uses thereof 黄泳华 2020-03-31 CN claimed
US-9586913-B2 Processes for the preparation of linezolid using novel intermediates SYMED LABS LIMITED (IN) 2017-03-07 US claimed
WO-2016113751-A1 PROCESS FOR PREPARING CRYSTALLINE LINEZOLID FORM-III NOSCH LABS PRIVATE LIMITED (IN) 2016-07-21 WO claimed
US-9376407-B2 Process for preparation of Linezolid and its novel intermediates LEE PHARMA LIMITED (IN) 2016-06-28 US claimed
US-20160102064-A1 IMPROVED PROCESSES FOR THE PREPARATION OF LINEZOLID USING NOVEL INTERMEDIATES SYMED LABS LIMITED (IN) 2016-04-14 US claimed
EP-2989097-A1 IMPROVED PROCESSES FOR THE PREPARATION OF LINEZOLID USING NOVEL INTERMEDIATES Symed Labs Limited (IN) 2016-03-02 EP claimed
EP-2595968-B1 NOVEL PROCESS FOR PREPARATION OF LINEZOLID AND ITS NOVEL INTERMEDIATES LEE PHARMA LTD (IN) 2015-09-09 EP claimed
EP-2902386-A1 A crystalline form of linezolid Symed Labs Limited (IN) 2015-08-05 EP claimed
EP-1861383-A2 ISOLATED BIS-LINEZOLID, PREPARATION THEREOF, AND ITS USE AS A REFERENCE STANDARD Teva Pharmaceutical Industries Ltd (IL) 2007-12-05 EP claimed
EP-1737850-B1 A NOVEL PROCESS FOR THE PREPARATION OF LINEZOLID AND RELATED COMPOUNDS SYMED LABS LTD (IN) 2007-10-03 EP claimed
EP-1768967-A1 NOVEL INTERMEDIATES FOR LINEZOLID AND RELATED COMPOUNDS Symed Labs Limited (IN) 2007-04-04 EP claimed
US-20070032472-A1 Novel process for the preparation of linezolid and related compounds SYMED LABS LIMITED (IN) 2007-02-08 US claimed
US-20060252932-A1 Isolated bis-linezolid, preparation thereof, and its use as a reference standard ENTIRE INTEREST 2006-11-09 US claimed
WO-2006091848-A9 ISOLATED BIS-LINEZOLID, PREPARATION THEREOF, AND ITS USE AS A REFERENCE STANDARD TEVA PHARMA (IL) 2006-11-09 WO claimed
US-20060247435-A1 Novel intermediates for linezolid and related compounds HETERO USA, INC. (US) 2006-11-02 US claimed
WO-2006091848-A2 ISOLATED BIS-LINEZOLID, PREPARATION THEREOF, AND ITS USE AS A REFERENCE STANDARD TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2006-08-31 WO claimed
US-20060128703-A1 Novel crystalline form of linezolid SYMED LABS LIMITED (IN) 2006-06-15 US claimed
WO-2006008754-A1 NOVEL INTERMEDIATES FOR LINEZOLID AND RELATED COMPOUNDS SYMED LABS LIMITED (IN) 2006-01-26 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160102064-A1 IMPROVED PROCESSES FOR THE PREPARATION OF LINEZOLID USING NOVEL INTERMEDIATES CYP3A5, SBDS, MLYCD MAOB 951/4885MAOA 522/4885PTGS1 2907/4885
US-20060128703-A1 Novel crystalline form of linezolid PYCARD, NLRP3, NLRP1 MAOB 3168/4885MAOA 2402/4885PTGS1 4691/4885
US-20060252932-A1 Isolated bis-linezolid, preparation thereof, and its use as a reference standard FHIT, CYP2C9, CYP2C19 MAOB 2182/4885MAOA 2591/4885PTGS1 4246/4885
US-20070032472-A1 Novel process for the preparation of linezolid and related compounds EED, EML4, KDM5D MAOB 946/4885MAOA 999/4885PTGS1 4504/4885
US-20060247435-A1 Novel intermediates for linezolid and related compounds HPD, PTMS, HDAC5 MAOB 1181/4885MAOA 1155/4885PTGS1 4327/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.