Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nedocromil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.59 |
| ▸ | TBK1 | Q9UHD2 | 20/20 | 0.59 |
| ▸ | IKBKE | Q14164 | 10/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.59 |
| ▸ | TTR | P02766 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.59 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nedocromil SCHEMBL29406688 | 0.78 | PDE5A (0.47) | KDM4EPKMGPR35 | |
| Nedocromil SCHEMBL4611 | 0.78 | PDE5A (0.47) | KDM4EPKMGPR35 | |
| Nedocromil SCHEMBL28341341 | 0.77 | PDE5A (0.46) | KDM4EPKMGPR35 | |
| Nedocromil SCHEMBL2879046 | 0.77 | PDE5A (0.46) | KDM4EPKMGPR35 | |
| Nedocromil SCHEMBL20481863 | 0.77 | PDE5A (0.46) | KDM4EPKMGPR35 | |
| Nedocromil SCHEMBL316743 | 0.77 | PDE5A (0.46) | KDM4EPKMGPR35 | |
| Nedocromil SCHEMBL667050 | 0.77 | PDE5A (0.46) | KDM4EPKMGPR35 | |
| Nedocromil SCHEMBL24943 | 0.77 | PDE5A (0.46) | KDM4EPKMGPR35 | |
| Amlexanox SCHEMBL5058549 | 0.77 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL29642 | 0.77 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4400163-A1 | COMPOSITIONS FOR THE TREATMENT OF GLUTEN INTOLERANCE AND USES THEREOF | Glutagen Pty Ltd (AU) | 2024-07-17 | — | — | EP | disclosed |
| US-20240026331-A1 | RECOMBINANT NEPROSIN POLYPEPTIDES AND METHODS OF EXPRESSION | CODEXIS, INC. | 2024-01-25 | — | — | US | disclosed |
| WO-2023220658-A2 | RECOMBINANT NEPROSIN POLYPEPTIDES AND METHODS OF EXPRESSION | CODEXIS, INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| US-11725198-B2 | Treatment of gluten intolerance and related conditions | CODEXIS, INC. (US) | 2023-08-15 | — | — | US | disclosed |
| US-11723960-B2 | Compositions and methods for treating gluten intolerance and disorders arising therefrom | CODEXIS, INC. (US) | 2023-08-15 | — | — | US | disclosed |
| US-11701411-B2 | Compositions and methods for treating gluten intolerance and disorders arising therefrom | CODEXIS, INC. (US) | 2023-07-18 | — | — | US | disclosed |
| US-20230173040-A1 | METHODS AND COMPOSITIONS FOR ATI DIGESTION | GLUTAGEN PTY LTD (AU) | 2023-06-08 | — | — | US | disclosed |
| EP-4149520-A1 | METHODS AND COMPOSITIONS FOR ATI DIGESTION | Glutagen Pty Ltd (AU) | 2023-03-22 | — | — | EP | disclosed |
| EP-3943104-A1 | COMPOSITIONS AND METHODS FOR TREATING GLUTEN INTOLERANCE AND DISORDERS ARISING THEREFROM | Codexis, Inc. (US) | 2022-01-26 | — | — | EP | disclosed |
| WO-2021226672-A1 | METHODS AND COMPOSITIONS FOR ATI DIGESTION | GLUTAGEN PTY LTD (AU) | 2021-11-18 | — | — | WO | disclosed |
| US-20080095710-A1 | ENZYME TREATMENT OF FOODSTUFFS FOR CELIAC SPRUE | The Board of Trustees of the Leland Stanford Junior University & Celiac Spruce Research | 2008-04-24 | — | — | US | disclosed |
| US-7320788-B2 | Enzyme treatment of foodstuffs for Celiac Sprue | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2008-01-22 | — | — | US | disclosed |
| US-7303871-B2 | Administering glutenase to Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating damaging effects of gluten | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2007-12-04 | — | — | US | disclosed |
| EP-1740197-A1 | THERAPEUTIC ENZYME FORMULATIONS AND USES THEREOF | Celiac Sprue Research Foundation (US) | 2007-01-10 | — | — | EP | disclosed |
| US-20060002917-A1 | Effect of prolyl endopeptidase on digestive-resistant gliadin peptides in vivo | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2006-01-05 | — | — | US | disclosed |
| WO-2005107786-A1 | THERAPEUTIC ENZYME FORMULATIONS AND USES THEREOF | CELIAC SPRUE RESEARCH FOUNDATION (US) | 2005-11-17 | — | — | WO | disclosed |
| US-20050249719-A1 | Enzyme treatment of foodstuffs for Celiac Sprue | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2005-11-10 | — | — | US | disclosed |
| EP-1572127-A2 | ENZYME TREATMENT OF FOODSTUFFS FOR CELIAC SPRUE | The Board of Trustees of The Leland Stanford Junior University (US) | 2005-09-14 | — | — | EP | disclosed |
| US-20030215438-A1 | Administering glutenase to Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating damaging effects of gluten | BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE | 2003-11-20 | — | — | US | disclosed |
| WO-2003068170-A2 | ENZYME TREATMENT OF FOODSTUFFS FOR CELIAC SPRUE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2003-08-21 | — | — | WO | disclosed |