Azetukalner

Azetukalner

SCHEMBL1000065

Cc1cc(N2CCc3cc(F)ccc3C2)cc(C)c1NC(=O)CC(C)(C)C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KCNQ2 O43526 20/20 1.00
KCNQ3 O43525 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Azetukalner SCHEMBL30429530 1.00 KCNQ2 (1.00) KCNQ2KCNQ3
SCHEMBL1001177 0.96 KCNQ2 (0.92) KCNQ2KCNQ3
SCHEMBL30796106 0.96 KCNQ2 (0.92) KCNQ2KCNQ3
Azetukalner SCHEMBL31441336 0.94 KCNQ2 (0.89) KCNQ2KCNQ3
SCHEMBL25101365 0.94 KCNQ2 (0.89) KCNQ2KCNQ3
SCHEMBL30814177 0.93 KCNQ2 (0.87) KCNQ2KCNQ3
SCHEMBL1003007 0.93 KCNQ2 (0.87) KCNQ2KCNQ3
Azetukalner SCHEMBL31441324 0.93 KCNQ2 (0.87) KCNQ2KCNQ3
SCHEMBL25286333 0.92 KCNQ2 (0.84) KCNQ2KCNQ3
SCHEMBL25244230 0.91 KCNQ2 (0.82) KCNQ2KCNQ3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 168 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250275957-A1 METHODS FOR ENHANCING THE BIOAVAILABILITY AND EXPOSURE OF A VOLTAGE-GATED POTASSIUM CHANNEL OPENER XENON PHARMACEUTICALS INC. (CA) 2025-09-04 US claimed
US-20250221980-A1 METHODS FOR ENHANCING THE BIOAVAILABILITY AND EXPOSURE OF A VOLTAGE-GATED POTASSIUM CHANNEL OPENER XENON PHARMACEUTICALS INC. (CA) 2025-07-10 US claimed
US-20250186426-A1 METHODS AND USES FOR TREATING ANHEDONIA XENON PHARMACEUTICALS INC. (CA) 2025-06-12 US claimed
US-12319657-B1 Solid state crystalline forms of a selective potassium channel modulator XENON PHARMACEUTICALS INC. (CA) 2025-06-03 US claimed
US-20250108044-A1 METHODS OF TREATING DEPRESSIVE DISORDERS XENON PHARMACEUTICALS INC. (CA) 2025-04-03 US claimed
US-12178811-B2 Methods of treating depressive disorders XENON PHARMACEUTICALS INC. (CA) 2024-12-31 US claimed
US-12171759-B1 Methods and uses for treating anhedonia XENON PHARMACEUTICALS INC. (CA) 2024-12-24 US claimed
US-20240408076-A1 METHODS AND USES FOR TREATING ANHEDONIA XENON PHARMACEUTICALS INC. (CA) 2024-12-12 US claimed
US-20240408075-A1 CONJOINT THERAPY FOR TREATING SEIZURE DISORDERS XENON PHARMACEUTICALS INC. (CA) 2024-12-12 US claimed
EP-4041713-B1 SOLID STATE CRYSTALLINE FORMS OF A SELECTIVE POTASSIUM CHANNEL MODULATOR XENON PHARMACEUTICALS INC (CA) 2024-12-11 EP claimed
US-20210213009-A1 METHODS OF TREATING PAIN XENON PHARMACEUTICALS INC. (CA) 2021-07-15 US claimed
US-20210161886-A1 METHODS OF TREATING DEPRESSIVE DISORDERS XENON PHARMACEUTICALS INC. (CA) 2021-06-03 US claimed
US-20210147363-A1 SOLID STATE CRYSTALLINE FORMS OF A SELECTIVE POTASSIUM CHANNEL MODULATOR XENON PHARMACEUTICALS INC. (CA) 2021-05-20 US claimed
EP-3790548-A1 METHODS FOR ENHANCING THE BIOAVAILABILITY AND EXPOSURE OF A VOLTAGE-GATED POTASSIUM CHANNEL OPENER Xenon Pharmaceuticals Inc. (CA) 2021-03-17 EP claimed
CN-112384216-A Methods for enhancing bioavailability and voltage-gated potassium ion channel open exposure 泽农医药公司 2021-02-19 CN claimed
US-20190343823-A1 METHODS FOR ENHANCING THE BIOAVAILABILITY AND EXPOSURE OF A VOLTAGE-GATED POTASSIUM CHANNEL OPENER XENON PHARMACEUTICALS INC. (CA) 2019-11-14 US claimed
WO-2019217924-A1 METHODS FOR ENHANCING THE BIOAVAILABILITY AND EXPOSURE OF A VOLTAGE-GATED POTASSIUM CHANNEL OPENER XENON PHARMACEUTICALS INC. (CA) 2019-11-14 WO claimed
EP-2061465-B1 DERIVATIVES OF 4-(N-AZACYCLOALKYL) ANILIDES AS POTASSIUM CHANNEL MODULATORS VALEANT PHARMACEUTICALS INT (US) 2013-04-10 EP claimed
US-8293911-B2 Seizure disorders; antiepileptic agents; N-(2-chloro-4-(3,4-dihydroisoquinolin-2(1H)-yl)-6-(trifluoromethyl)phenyl)-3,3-dimethylbutanamide for example VALEANT PHARMACEUTICALS INTERNATIONAL (US) 2012-10-23 US claimed
US-20080139610-A1 Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators VALEANT PHARMACEUTICALS NORTH AMERICA (US) 2008-06-12 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12171759-B1 Methods and uses for treating anhedonia CHAT, HNMT, PNMT KCNQ2 306/4885KCNQ3 221/4885
US-20080139610-A1 Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators KCNQ2, KCNQ1, KCNQ5 KCNQ2 1/4885KCNQ3 6/4885
US-20250186426-A1 METHODS AND USES FOR TREATING ANHEDONIA CHAT, HNMT, PNMT KCNQ2 306/4885KCNQ3 221/4885
US-20250275957-A1 METHODS FOR ENHANCING THE BIOAVAILABILITY AND EXPOSURE OF A VOLTAGE-GATED POTASSIUM CHANNEL OPENER KCNN3, KCNAB1, KCNQ2 KCNQ2 3/4885KCNQ3 7/4885
US-20250108044-A1 METHODS OF TREATING DEPRESSIVE DISORDERS HTR2A, PNMT, HTR3B KCNQ2 212/4885KCNQ3 123/4885
US-20240408075-A1 CONJOINT THERAPY FOR TREATING SEIZURE DISORDERS SMPD4, PNMT, NPY4R KCNQ2 30/4885KCNQ3 17/4885
US-20210147363-A1 SOLID STATE CRYSTALLINE FORMS OF A SELECTIVE POTASSIUM CHANNEL MODULATOR KCNQ2, KCNN2, KCNN3 KCNQ2 1/4885KCNQ3 9/4885
US-12178811-B2 Methods of treating depressive disorders HTR2A, PNMT, HTR3B KCNQ2 212/4885KCNQ3 123/4885
US-20210213009-A1 METHODS OF TREATING PAIN ACHE, OPRL1, METTL3 KCNQ2 198/4885KCNQ3 61/4885
US-20240408076-A1 METHODS AND USES FOR TREATING ANHEDONIA CHAT, HNMT, PNMT KCNQ2 306/4885KCNQ3 221/4885
US-20250221980-A1 METHODS FOR ENHANCING THE BIOAVAILABILITY AND EXPOSURE OF A VOLTAGE-GATED POTASSIUM CHANNEL OPENER KCNN3, KCNAB1, KCNQ2 KCNQ2 3/4885KCNQ3 7/4885
US-20190343823-A1 METHODS FOR ENHANCING THE BIOAVAILABILITY AND EXPOSURE OF A VOLTAGE-GATED POTASSIUM CHANNEL OPENER KCNN3, KCNAB1, KCNQ2 KCNQ2 3/4885KCNQ3 7/4885
US-12319657-B1 Solid state crystalline forms of a selective potassium channel modulator KCNQ2, KCNN2, KCNN3 KCNQ2 1/4885KCNQ3 9/4885
US-20210161886-A1 METHODS OF TREATING DEPRESSIVE DISORDERS HTR2A, PNMT, HTR3B KCNQ2 212/4885KCNQ3 123/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.