Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10008932 | 0.84 | L3MBTL1 (0.41) | L3MBTL1P2RX3MAPTLMNAKCNQ2 | |
| SCHEMBL10008966 | 0.83 | L3MBTL1 (0.48) | L3MBTL1P2RX3MAPTLMNAALDH1A1 | |
| SCHEMBL1492249 | 0.83 | SMN1; SMN2 (0.47) | L3MBTL1MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL1492335 | 0.79 | ALDH1A1 (0.52) | L3MBTL1MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL10008536 | 0.78 | L3MBTL1 (0.45) | L3MBTL1MAPTLMNAKCNQ2ALDH1A1 | |
| SCHEMBL1492267 | 0.78 | KMT2A (0.46) | L3MBTL1MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL1492382 | 0.77 | MAPK8 (0.51) | L3MBTL1MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL1492389 | 0.77 | KDM4E (0.43) | L3MBTL1MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL10007255 | 0.75 | POLB (0.43) | L3MBTL1MAPTLMNAKCNQ2SMN1; SMN2 | |
| SCHEMBL10008317 | 0.74 | MEN1 (0.42) | MAPTKCNQ2SMN1; SMN2POLBMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120172333-A1 | PYRROLO-PYRIDINE DERIVATIVES AS ACTIVATORS OF AMPK | GLAXOSMITHKLINE LLC (US) | 2012-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172333-A1 | PYRROLO-PYRIDINE DERIVATIVES AS ACTIVATORS OF AMPK | PRKAB1, PRKAG1, PRKAB2 | L3MBTL1 4828/4885P2RX3 873/4885MAPT 1823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.