Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | PPARG | P37231 | 1/20 | 0.63 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.63 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.63 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6796256 | 0.84 | ALDH1A1 (0.78) | RAB9AKMT2AHTTHSD17B10POLB | |
| SCHEMBL14208824 | 0.83 | NPC1 (0.69) | RAB9AKMT2AHTTHSD17B10POLB | |
| Ammonia Solution, Strong SCHEMBL28437729 | 0.82 | ALDH1A1 (0.76) | RAB9AKMT2AHTTHSD17B10POLB | |
| SCHEMBL13167581 | 0.77 | EPHX2 (0.69) | RAB9AKMT2APOLBALDH1A1MEN1 | |
| SCHEMBL4735011 | 0.77 | POLB (0.66) | RAB9AKMT2AHTTHSD17B10POLB | |
| SCHEMBL13650830 | 0.76 | NR1H4 (0.58) | RAB9AKMT2AHTTPOLBMEN1 | |
| SCHEMBL9429422 | 0.76 | MAPT (0.59) | RAB9AKMT2AHTTPOLBTSHR | |
| SCHEMBL19240371 | 0.76 | KIF11 (0.59) | RAB9AKMT2AHTTPOLBLMNA | |
| SCHEMBL2339823 | 0.75 | KMT2A (0.74) | RAB9AKMT2AHTTHSD17B10POLB | |
| SCHEMBL11867758 | 0.75 | SMN1; SMN2 (0.71) | RAB9AKMT2AHTTPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163788-B2 | Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors | RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITAT BONN (DE) | 2012-04-24 | — | — | US | disclosed |
| US-20100048594-A1 | USE OF CYTOHESIN INHIBITORS FOR CHEMICALLY INDUCING LONGEVITY | RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITAT (DE) | 2010-02-25 | — | — | US | disclosed |
| US-20090105286-A1 | Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors | RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITAT (DE) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048594-A1 | USE OF CYTOHESIN INHIBITORS FOR CHEMICALLY INDUCING LONGEVITY | IGFBP1, IGFBP2, IGFBP5 | RAB9A 3595/4885KMT2A 4710/4885HTT 34/4885 |
| US-20090105286-A1 | Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors | CYTH2, CYTH3, ENTPD5 | RAB9A 456/4885KMT2A 4540/4885HTT 3474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.