Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28288419 | 0.85 | MAPT (0.52) | L3MBTL1HPGDMAPTNPSR1KDM4E | |
| SCHEMBL10316560 | 0.84 | L3MBTL1 (0.53) | L3MBTL1CYP1A2CYP2C19TDP1CYP2D6 | |
| 1,2-Dipropoxybenzene SCHEMBL578657 | 0.83 | CYP1A2 (0.56) | L3MBTL1CYP1A2CYP2C19TDP1CYP2D6 | |
| 1,2-Dipropoxybenzene SCHEMBL29428926 | 0.83 | CYP1A2 (0.56) | L3MBTL1CYP1A2CYP2C19TDP1CYP2D6 | |
| 1,2-Dipropoxybenzene SCHEMBL8910053 | 0.81 | CYP1A2 (0.54) | L3MBTL1CYP1A2CYP2C19TDP1CYP2D6 | |
| SCHEMBL2380358 | 0.81 | L3MBTL1 (0.41) | L3MBTL1CYP1A2CYP2C19TDP1CYP2D6 | |
| SCHEMBL2350644 | 0.81 | AR (0.47) | L3MBTL1MAPTNPSR1KDM4EMEN1 | |
| SCHEMBL15473260 | 0.81 | RXRA (0.46) | L3MBTL1CYP1A2CYP2C19TDP1CYP2D6 | |
| SCHEMBL21385775 | 0.81 | L3MBTL1 (0.41) | L3MBTL1CYP1A2CYP2C19TDP1CYP2D6 | |
| SCHEMBL31186659 | 0.81 | L3MBTL1 (0.41) | L3MBTL1CYP1A2CYP2C19TDP1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938239-B2 | Method for preparing silodosin | SANDOZ AG (CH) | 2018-04-10 | — | — | US | disclosed |
| US-9932308-B2 | Method for producing indoline compound | UBE INDUSTRIES, LTD. (JP) | 2018-04-03 | — | — | US | disclosed |
| US-9745264-B2 | Method for preparing silodosin and intermediate thereof | SHANGHAI SYNCORES TECHNOLOGIES, INC. (CN) | 2017-08-29 | — | — | US | disclosed |
| US-20170197917-A1 | METHOD FOR PRODUCING INDOLINE COMPOUND | UBE INDUSTRIES, LTD. (JP) | 2017-07-13 | — | — | US | disclosed |
| US-9643921-B2 | Method for producing indoline compound | UBE INDUSTRIES, LTD. (JP) | 2017-05-09 | — | — | US | disclosed |
| US-20170008842-A1 | METHOD FOR PRODUCING INDOLINE COMPOUND | UBE INDUSTRIES, LTD. (JP) | 2017-01-12 | — | — | US | disclosed |
| EP-3103794-A1 | METHOD FOR PRODUCING INDOLINE COMPOUND | UBE Industries, Ltd. (JP) | 2016-12-14 | — | — | EP | disclosed |
| US-20160304452-A1 | METHOD FOR PREPARING SILODOSIN AND INTERMEDIATE THEREOF | ZHEJIANG HUAHAI PHARMACEUTICALS CO., LTD. (CN) | 2016-10-20 | — | — | US | disclosed |
| US-20160176818-A1 | Method For Preparing Silodosin | SANDOZ AG (CH) | 2016-06-23 | — | — | US | disclosed |
| US-20150038727-A1 | METHOD FOR PREPARING SILODOSIN | SANDOZ AG (CH) | 2015-02-05 | — | — | US | disclosed |
| US-8471039-B2 | Process for the preparation of indoline derivatives and their intermediates thereof | SANDOZ AG (CH) | 2013-06-25 | — | — | US | disclosed |
| US-20120165548-A1 | PROCESS FOR THE PREPARATION OF INDOLINE DERIVATIVES AND THEIR INTERMEDIATES THEREOF | SANDOZ AG (IN) | 2012-06-28 | — | — | US | disclosed |
| US-7834193-B2 | Indoline compound and process for producing the same | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2010-11-16 | — | — | US | disclosed |
| US-20070197627-A1 | Indoline compound and process for producting the same | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165548-A1 | PROCESS FOR THE PREPARATION OF INDOLINE DERIVATIVES AND THEIR INTERMEDIATES THEREOF | PIR, CYP3A4, CYP4A11 | L3MBTL1 4821/4885CYP1A2 13/4885CYP2C19 73/4885 |
| US-20160176818-A1 | Method For Preparing Silodosin | RCC2, RIOX2, CYP51A1 | L3MBTL1 3283/4885CYP1A2 368/4885CYP2C19 1115/4885 |
| US-20150038727-A1 | METHOD FOR PREPARING SILODOSIN | RCC2, RIOX2, CYP51A1 | L3MBTL1 3283/4885CYP1A2 368/4885CYP2C19 1115/4885 |
| US-20170008842-A1 | METHOD FOR PRODUCING INDOLINE COMPOUND | INMT, TPH1, IDO1 | L3MBTL1 4410/4885CYP1A2 107/4885CYP2C19 135/4885 |
| US-20160304452-A1 | METHOD FOR PREPARING SILODOSIN AND INTERMEDIATE THEREOF | PTMA, PIR, ERG28 | L3MBTL1 3673/4885CYP1A2 436/4885CYP2C19 1588/4885 |
| US-20070197627-A1 | Indoline compound and process for producting the same | BPHL, DAO, INHA | L3MBTL1 3972/4885CYP1A2 1443/4885CYP2C19 2629/4885 |
| US-20170197917-A1 | METHOD FOR PRODUCING INDOLINE COMPOUND | INMT, TPH1, INPP5A | L3MBTL1 4755/4885CYP1A2 355/4885CYP2C19 554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.