Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.49 |
| ▸ | NNMT | P40261 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12590041 | 0.90 | KDM4E (0.40) | HCAR3NNMTMAPTKDM4EKMT2A | |
| SCHEMBL12590062 | 0.87 | MEN1 (0.41) | MAPTKDM4EKMT2AMEN1NAMPT | |
| Hydrochloric Acid SCHEMBL2057832 | 0.86 | MEN1 (0.40) | MAPTKDM4EKMT2AMEN1NAMPT | |
| SCHEMBL12646651 | 0.85 | MEN1 (0.40) | MAPTKDM4EKMT2AMEN1NAMPT | |
| SCHEMBL24285410 | 0.82 | HCAR3 (0.51) | HCAR3NNMTMAPT | |
| SCHEMBL2057999 | 0.80 | AKT1 (0.46) | MAPTKDM4EKMT2AMEN1NAMPT | |
| SCHEMBL20037612 | 0.79 | HCAR3 (0.58) | HCAR3NNMTMAPTKDM4EKMT2A | |
| SCHEMBL16731692 | 0.76 | NPSR1 (0.58) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL32665265 | 0.75 | OPRM1 (0.50) | MAPTKMT2AMEN1NAMPTALDH1A1 | |
| SCHEMBL24285515 | 0.74 | HCAR3 (0.46) | HCAR3NNMTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8487080-B2 | Fluorine-labeled compounds | GENERAL ELECTRIC COMPANY (US) | 2013-07-16 | — | — | US | disclosed |
| US-8124725-B2 | PDGF-Rβ binders | GENERAL ELECTRIC COMPANY (US) | 2012-02-28 | — | — | US | disclosed |
| US-20110160430-A1 | FLUORINE-LABELED COMPOUNDS | GENERAL ELECTRIC COMPANY (US) | 2011-06-30 | — | — | US | disclosed |
| US-7902332-B2 | Reacting thiol-reactive terminus of linker with a polypeptide and fluorine-substituted aldehyde | GENERAL ELECTRIC COMPANY (US) | 2011-03-08 | — | — | US | disclosed |
| US-20090191124-A1 | PDGF-RBeta BINDERS | GENERAL ELECTRIC COMPANY (US) | 2009-07-30 | — | — | US | disclosed |
| US-20080139787-A1 | Fluorine-labeled compounds | GENERAL ELECTRIC COMPANY | 2008-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139787-A1 | Fluorine-labeled compounds | PFAS, DHFR, PAICS | HCAR3 1846/4885NNMT 1318/4885MAPT 2125/4885 |
| US-20110160430-A1 | FLUORINE-LABELED COMPOUNDS | PFAS, DHFR, PAICS | HCAR3 1846/4885NNMT 1318/4885MAPT 2125/4885 |
| US-20090191124-A1 | PDGF-RBeta BINDERS | PDGFRB, PDGFA, PDGFRA | HCAR3 1528/4885NNMT 4787/4885MAPT 3399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.