SCHEMBL10036670

SCHEMBL10036670

Nc1ccc(Sc2ccc(N)c(C(O)(C(F)(F)F)C(F)(F)F)c2)cc1C(O)(C(F)(F)F)C(F)(F)F

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.61
MLYCD O95822 2/20 0.43
MAPK1 P28482 4/20 0.42
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
MAPT P10636 3/20 0.42
KDM4E B2RXH2 3/20 0.42
LMNA P02545 2/20 0.42
HTT P42858 2/20 0.42
NPSR1 Q6W5P4 1/20 0.42
HSD17B10 Q99714 2/20 0.38
ALDH1A1 P00352 2/20 0.38
GLA P06280 1/20 0.38
POLB P06746 1/20 0.38
GAA P10253 1/20 0.38
HPGD P15428 1/20 0.38
ATM Q13315 1/20 0.38
TSHR P16473 3/20 0.34
ALOX15 P16050 1/20 0.34
CYP3A4 P08684 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10036581 0.93 SMN1; SMN2 (0.54) SMN1; SMN2MLYCDMAPK1MEN1KMT2A
SCHEMBL10002081 0.82 SMN1; SMN2 (0.45) SMN1; SMN2MLYCDMAPK1MEN1KMT2A
SCHEMBL1809687 0.80 PDE7A (0.41) SMN1; SMN2MAPK1KDM4EALDH1A1GLA
SCHEMBL18400632 0.79 MLYCD (0.44) SMN1; SMN2MLYCDMAPK1MEN1KMT2A
SCHEMBL10036532 0.79 SMN1; SMN2 (0.67) SMN1; SMN2MLYCDMAPK1MEN1KMT2A
SCHEMBL1635164 0.79 SMN1; SMN2 (0.67) SMN1; SMN2MLYCDMAPK1MEN1KMT2A
SCHEMBL10002094 0.77 CYP3A4 (0.42) SMN1; SMN2MLYCDMAPK1MEN1KMT2A
SCHEMBL12352871 0.76 SMN1; SMN2 (1.00) SMN1; SMN2MLYCDMAPK1MEN1KMT2A
SCHEMBL10036591 0.75 SMN1; SMN2 (0.61) SMN1; SMN2MAPK1MEN1KMT2AMAPT
SCHEMBL7187814 0.74 TSHR (0.52) MAPK1MEN1KMT2AMAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10384172-B2 Composite membrane with multi-layered active layer INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2019-08-20 US disclosed
US-10293308-B2 Antifouling and antimicrobial coatings for thin film composite membranes INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2019-05-21 US disclosed
US-20190015789-A1 ANTIFOULING AND ANTIMICROBIAL COATINGS FOR THIN FILM COMPOSITE MEMBRANES INTERNATIONAL BUSINESS MACHINES CORPORATION 2019-01-17 US disclosed
US-20170144113-A1 COMPOSITE MEMBRANE WITH MULTI-LAYERED ACTIVE LAYER INTERNATIONAL BUSINESS MACHINES CORPORATION 2017-05-25 US disclosed
US-9561474-B2 Composite membrane with multi-layered active layer INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2017-02-07 US disclosed
US-20170001151-A1 ANTIFOULING AND ANTIMICROBIAL COATINGS FOR THIN FILM COMPOSITE MEMBRANES INTERNATIONAL BUSINESS MACHINES CORPORATION 2017-01-05 US disclosed
US-9504967-B2 Composite membrane with multi-layered active layer GLOBALFOUNDRIES INC. (KY) 2016-11-29 US disclosed
EP-2398840-B1 INTERFACIAL POLYMERIZATION METHODS FOR MAKING FLUOROALCOHOL-CONTAINING POLYAMIDES IBM (US) 2016-07-13 EP disclosed
US-20140353253-A1 COMPOSITE MEMBRANE WITH MULTI-LAYERED ACTIVE LAYER GLOBALFOUNDRIES U.S. INC. 2014-12-04 US disclosed
US-8857629-B2 Composite membrane with multi-layered active layer INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2014-10-14 US disclosed
US-7728103-B2 Fluorine-containing polymerizable monomer and polymer compound using same CENTRAL GLASS COMPANY, LIMITED (JP) 2010-06-01 US disclosed
US-7629434-B2 Waterproofing; oil repellent; nonabsorber; heat resistance; weatherproofing; corrosion resistance; radiation transparent; photosensitivity; low refractive index and dielectrics CENTRAL GLASS COMPANY, LIMITED (JP) 2009-12-08 US disclosed
US-7629434-B2 Waterproofing; oil repellent; nonabsorber; heat resistance; weatherproofing; corrosion resistance; radiation transparent; photosensitivity; low refractive index and dielectrics CENTRAL GLASS COMPANY, LIMITED (JP) 2009-12-08 US disclosed
US-20090292104-A1 Polyamides from a dianiline compound where one or both of the rings is o-substituted with a 2-hydroxyhexafluoropropyl group and a di- or tetracarboxylic acid; polyimides; polybenzoxazines; repellency, oil repellency, low water absorption; resistance to heat, oil, water, & corrosion; low refractive index CENTRAL GLASS COMPANY, LIMITED (JP) 2009-11-26 US disclosed
US-20090292104-A1 Polyamides from a dianiline compound where one or both of the rings is o-substituted with a 2-hydroxyhexafluoropropyl group and a di- or tetracarboxylic acid; polyimides; polybenzoxazines; repellency, oil repellency, low water absorption; resistance to heat, oil, water, & corrosion; low refractive index CENTRAL GLASS COMPANY, LIMITED (JP) 2009-11-26 US disclosed
US-20090030173-A1 NOVEL FLUORINE-CONTAINING DICARBOXYLIC ACIDS AND THEIR NOVEL POLYMER COMPOUNDS CENTRAL GLASS COMPANY, LIMITED (JP) 2009-01-29 US disclosed
US-20090030173-A1 NOVEL FLUORINE-CONTAINING DICARBOXYLIC ACIDS AND THEIR NOVEL POLYMER COMPOUNDS CENTRAL GLASS COMPANY, LIMITED (JP) 2009-01-29 US disclosed
US-20080234460-A1 Fluorine-Containing Polymerizable Monomer and Polymer Compound Using Same CENTRAL GLASS CO., LTD. (JP) 2008-09-25 US disclosed
US-20080234460-A1 Fluorine-Containing Polymerizable Monomer and Polymer Compound Using Same CENTRAL GLASS CO., LTD. (JP) 2008-09-25 US disclosed
EP-1783158-A1 FLUORINE-CONTAINING POLYMERIZABLE MONOMER AND POLYMER COMPOUND USING SAME Central Glass Company, Limited (JP) 2007-05-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080234460-A1 Fluorine-Containing Polymerizable Monomer and Polymer Compound Using Same AFF2, FRG1, PFAS SMN1; SMN2 1644/4885MLYCD 4076/4885MAPK1 1210/4885
US-20090030173-A1 NOVEL FLUORINE-CONTAINING DICARBOXYLIC ACIDS AND THEIR NOVEL POLYMER COMPOUNDS AFF1, ODC1, DDC SMN1; SMN2 2624/4885MLYCD 161/4885MAPK1 534/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.