Sugi Predict

Sugi Predict / Compounds / SCHEMBL10039199

SCHEMBL10039199

SCHEMBL10039199

O=C(Nc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1Cl)c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 3/20 0.45
▸ KMT2A Q03164 3/20 0.45
▸ HDAC1 Q13547 2/20 0.41
▸ HDAC8 Q9BY41 2/20 0.41
▸ HDAC6 Q9UBN7 2/20 0.41
▸ TP53 P04637 1/20 0.39
▸ ALDH1A1 P00352 2/20 0.39
▸ KCNH2 Q12809 1/20 0.39
▸ ACLY P53396 2/20 0.39
▸ RAB9A P51151 2/20 0.39
▸ MAPT P10636 2/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ KDM4E B2RXH2 2/20 0.38
▸ NPSR1 Q6W5P4 1/20 0.38
▸ RXFP1 Q9HBX9 1/20 0.38
▸ HDAC2 Q92769 1/20 0.38
▸ CYP1A2 P05177 2/20 0.38
▸ MAPK1 P28482 1/20 0.37
▸ CYP3A4 P08684 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL566693 0.91 GAA (0.36) MEN1KMT2AALDH1A1KCNH2MAPT
SCHEMBL1547953 0.91 ALDH1A1 (0.41) KMT2AHDAC1HDAC8HDAC6TP53
SCHEMBL566522 0.89 CA1 (0.35) MEN1KMT2ATP53MAPTSMN1; SMN2
SCHEMBL1547616 0.88 HDAC1 (0.39) MEN1KMT2AHDAC1HDAC8HDAC6
SCHEMBL10039281 0.87 RAB9A (0.40) MEN1KMT2ATP53ALDH1A1RAB9A
SCHEMBL472296 0.87 PDK1 (0.36) MEN1KMT2ATP53RAB9AMAPT
SCHEMBL1547718 0.86 CYP3A4 (0.46) MEN1KMT2ARAB9AMAPTNPC1
SCHEMBL1547842 0.85 CA1 (0.35) TP53RAB9AMAPTNPC1SMN1; SMN2
SCHEMBL1548031 0.84 POLB (0.40) KMT2ATP53RAB9AMAPTNPC1
SCHEMBL13299438 0.84 MEN1 (0.34) MEN1KMT2AHDAC1HDAC8TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8785485-B2 Animal ectoparasite-controlling agent SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-07-22 — — US disclosed
US-8785485-B2 Animal ectoparasite-controlling agent SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-07-22 — — US disclosed
US-8507514-B2 Hydrazide compound and use of the same in pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-08-13 — — US disclosed
US-8507514-B2 Hydrazide compound and use of the same in pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-08-13 — — US disclosed
EP-2601835-A1 PEST CONTROL COMPOSITION Sumitomo Chemical Co., Ltd (JP) 2013-06-12 — — EP disclosed
US-20130137682-A1 PEST CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-30 — — US disclosed
US-20130137682-A1 PEST CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-30 — — US disclosed
US-20130131116-A1 PEST CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-23 — — US disclosed
US-20130131117-A1 PEST CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-23 — — US disclosed
US-20130131117-A1 PEST CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-23 — — US disclosed
US-20120035218-A1 PEST CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-02-09 — — US disclosed
WO-2012017973-A1 PEST CONTROL COMPOSITION 住友化学株式会社 (JP) 2012-02-09 — — WO disclosed
WO-2012017970-A1 PEST CONTROL COMPOSITION 住友化学株式会社 (JP) 2012-02-09 — — WO disclosed
WO-2012017971-A1 PEST CONTROL COMPOSITION 住友化学株式会社 (JP) 2012-02-09 — — WO disclosed
WO-2012017969-A1 PEST CONTROL COMPOSITION 住友化学株式会社 (JP) 2012-02-09 — — WO disclosed
US-20120029038-A1 ANIMAL ECTOPARASITE-CONTROLLING AGENT SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-02-02 — — US disclosed
US-20120029038-A1 ANIMAL ECTOPARASITE-CONTROLLING AGENT SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-02-02 — — US disclosed
US-20110294840-A1 HYDRAZIDE COMPOUND AND USE OF THE SAME IN PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-12-01 — — US disclosed
US-20110294840-A1 HYDRAZIDE COMPOUND AND USE OF THE SAME IN PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-12-01 — — US disclosed
WO-2010090344-A1 HYDRAZIDE COMPOUND AND USE OF THE SAME IN PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-08-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130137682-A1 PEST CONTROL COMPOSITION H1-4, HRH4, CHRM2 MEN1 1910/4885KMT2A 992/4885HDAC1 301/4885
US-20110294840-A1 HYDRAZIDE COMPOUND AND USE OF THE SAME IN PEST CONTROL H1-4, H1-2, H1-0 MEN1 1591/4885KMT2A 420/4885HDAC1 37/4885
US-20130131116-A1 PEST CONTROL COMPOSITION H1-4, H1-10, H1-0 MEN1 1323/4885KMT2A 531/4885HDAC1 64/4885
US-20120029038-A1 ANIMAL ECTOPARASITE-CONTROLLING AGENT H1-3, HRH4, EEF1A1 MEN1 1206/4885KMT2A 264/4885HDAC1 29/4885
US-20130131117-A1 PEST CONTROL COMPOSITION H1-4, H1-0, H1-2 MEN1 625/4885KMT2A 572/4885HDAC1 122/4885
US-20120035218-A1 PEST CONTROL COMPOSITION CTRL, CYP4F3, CYP4B1 MEN1 2851/4885KMT2A 533/4885HDAC1 168/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.