Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.61 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15307422 | 0.87 | KIF18A (0.68) | HTR6KIF18AKMT2AMEN1RAB9A | |
| SCHEMBL10040106 | 0.79 | HTR6 (0.67) | HTR6CYP11B1CYP11B2MEN1RXFP1 | |
| SCHEMBL1663904 | 0.78 | CYP11B1 (0.57) | CYP11B1CYP11B2MEN1RAB9ACA12 | |
| SCHEMBL10040087 | 0.76 | HTR6 (1.00) | HTR6CYP11B1CYP11B2RXFP1CA12 | |
| SCHEMBL10905079 | 0.76 | KMT2A (0.66) | HTR6KIF18AKMT2AMEN1RAB9A | |
| SCHEMBL29914888 | 0.75 | HTR6 (0.61) | HTR6CYP11B1CYP11B2RXFP1CA12 | |
| SCHEMBL4704336 | 0.74 | ERN1 (0.56) | CYP11B1CYP11B2CA12CA1CA2 | |
| SCHEMBL1980117 | 0.74 | CYP11B1 (0.51) | CYP11B1CYP11B2MEN1RAB9ACA12 | |
| SCHEMBL29580441 | 0.74 | TDP1 (0.67) | KMT2ACYP11B1CYP11B2MEN1RAB9A | |
| SCHEMBL77083 | 0.74 | TDP1 (0.67) | KMT2ACYP11B1CYP11B2MEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3072882-A1 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR THE PRODUCTION AND USE THEREOF | Alla Chem, LLC. (US) | 2016-09-28 | — | — | EP | disclosed |
| US-8829002-B2 | Substituted methyl amines, serotonin 5-HT6 receptor antagonists, methods for production and use thereof | IVACHTCHENKO ALEXANDRE VASILIEVICH (US) | 2014-09-09 | — | — | US | disclosed |
| US-8829002-B2 | Substituted methyl amines, serotonin 5-HT6 receptor antagonists, methods for production and use thereof | IVACHTCHENKO ALEXANDRE VASILIEVICH (US) | 2014-09-09 | — | — | US | disclosed |
| US-20130267536-A1 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR PRODUCTION AND USE THEREOF | ALLA CHEM, LLC (US) | 2013-10-10 | — | — | US | disclosed |
| US-20130267536-A1 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR PRODUCTION AND USE THEREOF | ALLA CHEM, LLC (US) | 2013-10-10 | — | — | US | disclosed |
| WO-2012087182-A2 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ, ЛЛС (US) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130267536-A1 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR PRODUCTION AND USE THEREOF | HTR6, HTR1F, HTR1A | HTR6 1/4885KIF18A 3510/4885KMT2A 842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.