Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.69 |
| ▸ | CYP19A1 | P11511 | 9/20 | 0.66 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL230368 | 0.91 | HSP90AB1 (0.82) | HSP90AB1CYP19A1NPC1RAB9AHRH4 | |
| SCHEMBL30959784 | 0.89 | HSP90AB1 (0.80) | HSP90AB1CYP19A1NPC1RAB9AHRH4 | |
| SCHEMBL21293881 | 0.89 | HSP90AB1 (0.80) | HSP90AB1CYP19A1NPC1RAB9AHRH4 | |
| SCHEMBL17104470 | 0.88 | CYP19A1 (0.67) | HSP90AB1CYP19A1SIGMAR1NPC1RAB9A | |
| SCHEMBL15425743 | 0.86 | CYP19A1 (0.67) | HSP90AB1CYP19A1NPC1RAB9AHRH4 | |
| SCHEMBL29055929 | 0.84 | CYP19A1 (0.65) | HSP90AB1CYP19A1NPC1RAB9AHRH4 | |
| SCHEMBL18028297 | 0.82 | HSP90AB1 (0.70) | HSP90AB1CYP19A1NPC1RAB9A | |
| SCHEMBL15014123 | 0.82 | CYP19A1 (0.76) | HSP90AB1CYP19A1NPC1RAB9AHRH4 | |
| SCHEMBL28923930 | 0.82 | CYP19A1 (0.58) | HSP90AB1CYP19A1SIGMAR1NPC1RAB9A | |
| Sulfuric Acid SCHEMBL28657977 | 0.81 | HSP90AB1 (0.68) | HSP90AB1CYP19A1NPC1RAB9AHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507769-B2 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | SCRIPPS RESEARCH INST (US) | 2017-10-11 | — | — | EP | disclosed |
| US-20160214946-A1 | CATALYSED LIGATION OF AZIDES AND ACETYLENES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-07-28 | — | — | US | disclosed |
| US-9302997-B2 | Copper-catalysed ligation of azides and acetylenes | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-04-05 | — | — | US | disclosed |
| EP-2226316-B1 | Copper-catalysed ligation of azides and acetylenes | SCRIPPS RESEARCH INST (US) | 2016-01-13 | — | — | EP | disclosed |
| US-20150232432-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-08-20 | — | — | US | disclosed |
| US-9040716-B2 | Copper-catalysed ligation of azides and acetylenes | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-05-26 | — | — | US | disclosed |
| US-20150031895-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-01-29 | — | — | US | disclosed |
| US-8877939-B2 | Copper-catalysed ligation of azides and acetylenes | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-11-04 | — | — | US | disclosed |
| US-20140066632-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-03-06 | — | — | US | disclosed |
| US-8580970-B2 | Copper-catalysed ligation of azides and acetylenes | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-11-12 | — | — | US | disclosed |
| US-20120165542-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-06-28 | — | — | US | disclosed |
| EP-2226316-A1 | Copper-catalysed ligation of azides and acetylenes | The Scripps Research Institute (US) | 2010-09-08 | — | — | EP | disclosed |
| EP-1507769-B1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | SCRIPPS RESEARCH INST (US) | 2010-05-26 | — | — | EP | disclosed |
| US-20080214831-A1 | Contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion for a time sufficient to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole; high yields and high purity | THE SCRIPPS RESEARCH INSTITUTE | 2008-09-04 | — | — | US | disclosed |
| US-7375234-B2 | regiospecifically ligates azides and terminal acetylenes to give only 1,4-disubstituted [1,2,3]-triazoles; stepwise Huisgen cycloaddition process catalyzed by copper | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150232432-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | SOD1, AOC3, AOC2 | HSP90AB1 4428/4885CYP19A1 1934/4885SIGMAR1 3249/4885 |
| US-20080214831-A1 | Contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion for a time sufficient to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole; high yields and high purity | AOC3, AOC2, ADH1C | HSP90AB1 3258/4885CYP19A1 3766/4885SIGMAR1 713/4885 |
| US-20120165542-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | AOC3, ADH1C, AOC2 | HSP90AB1 2943/4885CYP19A1 2969/4885SIGMAR1 1205/4885 |
| US-20160214946-A1 | CATALYSED LIGATION OF AZIDES AND ACETYLENES | AOC3, AOC2, KARS1 | HSP90AB1 4081/4885CYP19A1 1159/4885SIGMAR1 2268/4885 |
| US-20150031895-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | AOC3, SOD1, AOC2 | HSP90AB1 3791/4885CYP19A1 2247/4885SIGMAR1 2812/4885 |
| US-20140066632-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | AOC3, SOD1, AOC2 | HSP90AB1 3791/4885CYP19A1 2247/4885SIGMAR1 2812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.