Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTR1E | P28566 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3438874 | 0.92 | GAA (0.41) | GAAAAK1ACKR3NPSR1CRHBP | |
| SCHEMBL15120774 | 0.82 | GAA (0.49) | GAAAAK1NPSR1CRHBPCRHR2 | |
| SCHEMBL10084269 | 0.78 | GAA (0.46) | GAAAAK1ACKR3NPSR1CRHBP | |
| SCHEMBL15119804 | 0.76 | CETP (0.56) | GAANPSR1KMT2ALMNAHPGD | |
| SCHEMBL10046434 | 0.72 | SMN1; SMN2 (0.58) | GAAMEN1KMT2AMAPTHPGD | |
| SCHEMBL3438878 | 0.71 | CETP (0.58) | NPSR1MEN1KMT2ALMNAMAPT | |
| SCHEMBL10073854 | 0.71 | HSD17B10 (0.64) | MEN1KMT2ALMNAHPGDHTT | |
| SCHEMBL10826670 | 0.69 | GAA (0.43) | GAAAAK1ACKR3NPSR1MEN1 | |
| SCHEMBL10046433 | 0.68 | MDM4 (0.58) | GAANPSR1MEN1KMT2ALMNA | |
| SCHEMBL13999152 | 0.68 | MAPT (0.50) | GAAAAK1NPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130184456-A1 | HETEROCYCLIC MACROCYCLE TEMPLATED METAL-ORGANIC MATERIALS | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-07-18 | — | — | US | disclosed |
| US-20130030170-A1 | ENANTIOSELECTIVE CYCLOPROPENATION OF ALKYNES | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-01-31 | — | — | US | disclosed |
| US-20130023403-A1 | METAL ORGANIC MATERIALS AS BIOMIMETIC ENZYMES | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-01-24 | — | — | US | disclosed |
| US-20130023403-A1 | METAL ORGANIC MATERIALS AS BIOMIMETIC ENZYMES | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-01-24 | — | — | US | disclosed |
| US-20120077959-A1 | Asymmetric Cobalt-Catalyzed Cyclopropanation With Succinimidyl Diazoacetate | NATIONAL SCIENCE FOUNDATION | 2012-03-29 | — | — | US | disclosed |
| US-20120077990-A1 | Alkene Aziridination | NATIONAL SCIENCE FOUNDATION | 2012-03-29 | — | — | US | disclosed |
| US-20120077990-A1 | Alkene Aziridination | NATIONAL SCIENCE FOUNDATION | 2012-03-29 | — | — | US | disclosed |
| US-20120046455-A1 | Catalytic Cyclopropanation of Alkenes with Alpha-Cyano-Diazoacetates | NATIONAL SCIENCE FOUNDATION | 2012-02-23 | — | — | US | disclosed |
| US-8110699-B2 | Cobalt-catalyzed asymmetric cyclopropanation of alkenes with α-nitrodiazoacetates | UNIVERSITY OF SOUTH FLORIDA (US) | 2012-02-07 | — | — | US | disclosed |
| US-8110699-B2 | Cobalt-catalyzed asymmetric cyclopropanation of alkenes with α-nitrodiazoacetates | UNIVERSITY OF SOUTH FLORIDA (US) | 2012-02-07 | — | — | US | disclosed |
| US-20110207956-A1 | INTRAMOLECULAR C-H AMINATION WITH PHOSPHORYL AZIDES | NATIONAL SCIENCE FOUNDATION | 2011-08-25 | — | — | US | disclosed |
| US-20100081838-A1 | Cobalt-Catalyzed Asymmetric Cyclopropanation of Alkenes with alpha-Nitrodiazoacetates | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-04-01 | — | — | US | disclosed |
| US-20100081838-A1 | Cobalt-Catalyzed Asymmetric Cyclopropanation of Alkenes with alpha-Nitrodiazoacetates | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046455-A1 | Catalytic Cyclopropanation of Alkenes with Alpha-Cyano-Diazoacetates | PPOX, POR, PCCA | GAA 1559/4885AAK1 1236/4885ACKR3 3828/4885 |
| US-20130030170-A1 | ENANTIOSELECTIVE CYCLOPROPENATION OF ALKYNES | CYCS, CBR3, HCCS | GAA 4455/4885AAK1 3318/4885ACKR3 1044/4885 |
| US-20110207956-A1 | INTRAMOLECULAR C-H AMINATION WITH PHOSPHORYL AZIDES | CYCS, CCNH, CBR3 | GAA 2576/4885AAK1 2724/4885ACKR3 3607/4885 |
| US-20130184456-A1 | HETEROCYCLIC MACROCYCLE TEMPLATED METAL-ORGANIC MATERIALS | ORC3, MCM4, MCM7 | GAA 2248/4885AAK1 2117/4885ACKR3 1754/4885 |
| US-20100081838-A1 | Cobalt-Catalyzed Asymmetric Cyclopropanation of Alkenes with alpha-Nitrodiazoacetates | PPOX, IDH3A, HMOX2 | GAA 3727/4885AAK1 2304/4885ACKR3 1800/4885 |
| US-20120077990-A1 | Alkene Aziridination | AZI2, PPOX, GLI2 | GAA 2108/4885AAK1 881/4885ACKR3 3012/4885 |
| US-20120077959-A1 | Asymmetric Cobalt-Catalyzed Cyclopropanation With Succinimidyl Diazoacetate | SI, STOM, SUCLA2 | GAA 2601/4885AAK1 3456/4885ACKR3 1416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.