Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13790821 | 0.87 | CYP1A2 (0.54) | CYP1A2KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL6788100 | 0.84 | CYP1A2 (1.00) | CYP1A2KMT2AALDH1A1GAAHPGD | |
| SCHEMBL13791042 | 0.82 | CYP1A2 (0.48) | CYP1A2KMT2AALDH1A1MAPTHSD17B10 | |
| SCHEMBL29640755 | 0.82 | POLB (0.56) | CYP1A2ALDH1A1KDM4EMAPTPPARG | |
| SCHEMBL511950 | 0.82 | POLB (0.56) | CYP1A2ALDH1A1KDM4EMAPTPPARG | |
| SCHEMBL7827480 | 0.82 | GAA (0.53) | KMT2AALDH1A1MAPTGAAHPGD | |
| SCHEMBL13791024 | 0.81 | CYP1A2 (0.47) | CYP1A2KMT2AALDH1A1MAPTHPGD | |
| SCHEMBL3256326 | 0.80 | NPC1 (0.62) | KMT2AALDH1A1MAPTGAATSHR | |
| SCHEMBL1802183 | 0.79 | ALDH1A1 (0.56) | CYP1A2ALDH1A1KDM4EMAPTPPARG | |
| SCHEMBL7369701 | 0.79 | CYP1A2 (0.70) | CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178781-A1 | KAPPA OPIOID RECEPTOR LIGANDS | RESEARCH TRIANGLE INSTITUTE (US) | 2012-07-12 | — | — | US | disclosed |
| US-8173678-B2 | Kappa opioid receptor ligands | RESEARCH TRIANGLE INSTITUTE (US) | 2012-05-08 | — | — | US | disclosed |
| US-20110065743-A1 | KAPPA OPIOID RECEPTOR LIGANDS | RESEARCH TRIANGLE INSTITUTE (US) | 2011-03-17 | — | — | US | disclosed |
| US-7872023-B2 | administering 6-Hydroxy-1,2,3,4-tetrahydro-naphthalene-2(-)-carboxylic acid{1-[4-(3-hydroxyphenyl)-(3R)-(4R)-trans-dimethyl-piperidinylmethyl]-(2S)-methylpropyl}-amide, for the treatment of drug abuse and dependence | RESEARCH TRIANGLE INSTITUTE (US) | 2011-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065743-A1 | KAPPA OPIOID RECEPTOR LIGANDS | OPRK1, OPRD1, OPRM1 | CYP1A2 2289/4885KMT2A 2276/4885ALDH1A1 2101/4885 |
| US-20120178781-A1 | KAPPA OPIOID RECEPTOR LIGANDS | OPRK1, OPRD1, OPRM1 | CYP1A2 2289/4885KMT2A 2276/4885ALDH1A1 2101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.