Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 14/20 | 0.64 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.54 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.54 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16544803 | 0.94 | ACHE (0.58) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL17550827 | 0.89 | ACHE (0.59) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL14201320 | 0.88 | ACHE (0.85) | ACHE | |
| Ammonia Solution, Strong SCHEMBL9998424 | 0.85 | ACHE (0.55) | ACHEMEN1KMT2AALDH1A1 | |
| SCHEMBL28158857 | 0.85 | ACHE (0.72) | ACHE | |
| SCHEMBL5700191 | 0.85 | ACHE (0.65) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL11989433 | 0.83 | ACHE (0.76) | ACHE | |
| SCHEMBL15132643 | 0.83 | ACHE (0.76) | ACHE | |
| SCHEMBL16526224 | 0.83 | ACHE (0.76) | ACHE | |
| SCHEMBL11378769 | 0.83 | ACHE (0.64) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242984-B2 | Pyrazolyl derivatives as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-01-26 | — | — | US | disclosed |
| US-9187546-B2 | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants | NOVO NORDISK A/S (DK) | 2015-11-17 | — | — | US | disclosed |
| US-20150191461-A1 | PYRAZOLYL DERIVATIVES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-07-09 | — | — | US | disclosed |
| US-20120165275-A1 | Nitrogen-Based Linkers for Attaching Modifying Groups to Polypeptides and Other Macromolecules | AFFYMAX, INC. (US) | 2012-06-28 | — | — | US | disclosed |
| US-20110245258-A1 | NOVEL ANTIMICROBIALS | PANACEA BIOTEC LTD. (IN) | 2011-10-06 | — | — | US | disclosed |
| US-20090124544-A1 | COMPOSITIONS AND METHODS FOR THE PREPARATION OF PROTEASE RESISTANT HUMAN GROWTH HORMONE GLYCOSYLATION MUTANTS | NEOSE TECHNOLOGIES ,INC. A DELAWARE CORPORATION | 2009-05-14 | — | — | US | disclosed |
| US-7270928-B2 | Isocyanate composition, microcapsule and production method thereof, and recording material | FUJIFILM CORPORATION (JP) | 2007-09-18 | — | — | US | disclosed |
| US-7270928-B2 | Isocyanate composition, microcapsule and production method thereof, and recording material | FUJIFILM CORPORATION (JP) | 2007-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150191461-A1 | PYRAZOLYL DERIVATIVES AS SYK INHIBITORS | SYK, BTK, LCK | ACHE 1495/4885CHRNB2 3012/4885CHRNB4 3294/4885 |
| US-20120165275-A1 | Nitrogen-Based Linkers for Attaching Modifying Groups to Polypeptides and Other Macromolecules | DNPEP, NGLY1, LNPEP | ACHE 1849/4885CHRNB2 3406/4885CHRNB4 3410/4885 |
| US-20110245258-A1 | NOVEL ANTIMICROBIALS | ECI1, XDH, CYP3A4 | ACHE 3387/4885CHRNB2 4721/4885CHRNB4 4261/4885 |
| US-20090124544-A1 | COMPOSITIONS AND METHODS FOR THE PREPARATION OF PROTEASE RESISTANT HUMAN GROWTH HORMONE GLYCOSYLATION MUTANTS | GHITM, PTMS, GHRHR | ACHE 4414/4885CHRNB2 3359/4885CHRNB4 3413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.