Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Brotizolam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 known ✓ | P47869 | 3/20 | 0.56 |
| ▸ | PTAFR | P25105 | 15/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Brotizolam SCHEMBL44067 | 0.80 | PTAFR (1.00) | PTAFRADRA1AGABRA1GABRA5GABRA3 | |
| Brotizolam SCHEMBL29396298 | 0.80 | PTAFR (1.00) | PTAFRADRA1AGABRA1GABRA5GABRA3 | |
| Alprazolam SCHEMBL3664716 | 0.79 | GABRA1 (0.66) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| Bromazepam SCHEMBL29382152 | 0.76 | ADRA1A (1.00) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| Bromazepam SCHEMBL29521776 | 0.76 | ADRA1A (1.00) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| Bromazepam SCHEMBL43933 | 0.76 | ADRA1A (1.00) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| Bromazepam SCHEMBL29366892 | 0.76 | ADRA1A (1.00) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| Phenazepam SCHEMBL29368536 | 0.75 | GABRA1 (1.00) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| Phenazepam SCHEMBL416137 | 0.75 | GABRA1 (1.00) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL11512288 | 0.74 | PTAFR (0.64) | PTAFRGABRA1GABRA5GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593104-A2 | METHODS OF TREATING AND PREVENTING/REDUCING THE LIKELIHOOD OF MESIAL TEMPORAL LOBE EPILEPSY (TLE) | Müller, Prof. Dr., Wolfgang (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2011011692-A2 | METHODS OF TREATING AND PREVENTING/REDUCING THE LIKELIHOOD OF MESIAL TEMPORAL LOBE EPILEPSY (TLE) | STC.UNM (US) | 2011-01-27 | — | — | WO | disclosed |