Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Alprazolam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 8/20 | 0.66 |
| ▸ | GABRA5 known ✓ | P31644 | 8/20 | 0.66 |
| ▸ | GABRA2 known ✓ | P47869 | 8/20 | 0.66 |
| ▸ | GABRB2 known ✓ | P47870 | 7/20 | 0.66 |
| ▸ | GABRA3 known ✓ | P34903 | 6/20 | 0.66 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.49 |
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | CNR1 | P21554 | 2/20 | 0.60 |
| ▸ | BRD4 | O60885 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.53 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adinazolam SCHEMBL28086683 | 0.89 | OPRK1 (0.63) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| Diazepam SCHEMBL8329713 | 0.86 | ADRA1A (0.64) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11620342 | 0.81 | GABRA1 (0.77) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL29385106 | 0.81 | GABRA1 (1.00) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11624016 | 0.81 | GABRA1 (1.00) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| Diazepam SCHEMBL10351230 | 0.79 | ADRA1A (0.54) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| Brotizolam SCHEMBL1005083 | 0.79 | PTAFR (0.64) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| Alprazolam SCHEMBL16922178 | 0.78 | GABRA1 (1.00) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| Alprazolam SCHEMBL8398 | 0.78 | GABRA1 (1.00) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| Alprazolam SCHEMBL5480614 | 0.78 | GABRA1 (1.00) | GABRA1GABRA5GABRA2GABRB2GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2219612-A1 | MISUSE PREVENTATIVE, CONTROLLED RELEASE FORMULATION | Labopharm Inc. (CA) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009076764-A1 | MISUSE PREVENTATIVE, CONTROLLED RELEASE FORMULATION | LABOPHARM INC. (CA) | 2009-06-25 | — | — | WO | disclosed |