SCHEMBL100524

SCHEMBL100524

CC(C)(C)[Si](C)(C)OCc1ccc(NC(=O)CCc2ccc(-c3ccccc3)c(NC(=O)O)c2)cc1F

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RORC P51449 1/20 0.43
HCAR2 Q8TDS4 6/20 0.42
CDK8 P49336 1/20 0.39
MAPT P10636 2/20 0.38
MEN1 O00255 2/20 0.38
ALDH1A1 P00352 2/20 0.38
KMT2A Q03164 2/20 0.38
CYP3A4 P08684 1/20 0.38
TSHR P16473 1/20 0.38
MAPKAPK2 P49137 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
RAB9A P51151 2/20 0.37
LMNA P02545 1/20 0.37
NPC1 O15118 1/20 0.37
FFAR1 O14842 2/20 0.36
FFAR4 Q5NUL3 2/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC2 Q92769 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL102843 0.92 HCAR2 (0.42) RORCHCAR2MAPTKMT2ATSHR
SCHEMBL101812 0.90 PTGDR2 (0.42) RORCHCAR2CDK8MAPTRAB9A
SCHEMBL99071 0.89 RAB9A (0.43) HCAR2MEN1KMT2ATSHRSMN1; SMN2
SCHEMBL99813 0.89 HCAR2 (0.44) RORCHCAR2MAPTRAB9AHDAC1
SCHEMBL99078 0.86 HCAR2 (0.42) HCAR2MAPTMEN1ALDH1A1KMT2A
SCHEMBL174745 0.85 CHRM3 (0.47)
SCHEMBL102082 0.85 RAB9A (0.44) RORCHCAR2SMN1; SMN2RAB9ANPC1
SCHEMBL100167 0.85 SMN1; SMN2 (0.43) HCAR2MAPTMEN1ALDH1A1KMT2A
SCHEMBL99375 0.85 NPC1 (0.49) MAPTMEN1ALDH1A1KMT2ACYP3A4
SCHEMBL102179 0.84 NPC1 (0.42) MAPTMEN1ALDH1A1KMT2ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2426121-A1 QUATERNARY AMMONIUM SALT COMPOUND Teijin Pharma Limited (JP) 2012-03-07 EP claimed