Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CTSD | P07339 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10054186 | 0.84 | GAA (0.58) | POLBALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6093048 | 0.82 | ERCC1 (0.66) | POLBKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL10053738 | 0.81 | POLB (1.00) | POLBALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL5018017 | 0.80 | ALDH1A1 (0.66) | POLBKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL10053820 | 0.80 | RECQL (0.62) | POLBKDM4ERECQLALDH1A1MEN1 | |
| SCHEMBL14644169 | 0.80 | ALDH1A1 (0.70) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2610079 | 0.79 | EPHX2 (0.60) | POLBKDM4ERECQLALDH1A1SMN1; SMN2 | |
| SCHEMBL9028853 | 0.79 | ALDH1A1 (0.68) | POLBKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14644110 | 0.78 | LMNA (0.55) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10053699 | 0.77 | HEXD (0.66) | POLBKDM4ERECQLALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8906945-B2 | Inhibitors of bacterial type III secretion system | MICROBIOTIX, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20120114633-A1 | Inhibitors Of Bacterial Type III Secretion System | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114633-A1 | Inhibitors Of Bacterial Type III Secretion System | CLPP, TFPI, SI | POLB 2380/4885KDM4E 4731/4885RECQL 697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.