Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.55 |
| ▸ | PADI4 | Q9UM07 | 12/20 | 0.48 |
| ▸ | PADI2 | Q9Y2J8 | 9/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | PADI6 | Q6TGC4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10060140 | 0.92 | MCHR1 (0.56) | MCHR1PADI4PADI2PSMB5NFKB1 | |
| SCHEMBL10060574 | 0.84 | HDAC1 (0.66) | MCHR1PADI4PADI2PSMB5NFKB1 | |
| SCHEMBL10060142 | 0.80 | KDM1A (0.58) | PADI4PADI6 | |
| SCHEMBL10060143 | 0.79 | PADI6 (0.62) | PADI4PADI2PDE4APDE4BPDE4C | |
| SCHEMBL10060144 | 0.76 | HDAC1 (0.67) | MCHR1PADI4PADI2HDAC1PADI6 | |
| SCHEMBL6368422 | 0.74 | PYGL (0.51) | MCHR1HDAC1HDAC3HDAC2 | |
| SCHEMBL24627779 | 0.73 | PADI4 (0.42) | MCHR1PADI4PADI2PDE4APDE4B | |
| SCHEMBL30804858 | 0.73 | PADI4 (0.42) | MCHR1PADI4PADI2PDE4APDE4B | |
| SCHEMBL27174806 | 0.73 | PADI4 (0.42) | MCHR1PADI4PADI2PDE4APDE4B | |
| SCHEMBL10060141 | 0.73 | KDM1A (0.57) | PADI4PADI2PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108562-A1 | THERAPEUTIC COMPOSITIONS AND METHODS | THE PENN STATE RESEARCH FOUNDATION (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108562-A1 | THERAPEUTIC COMPOSITIONS AND METHODS | PADI4, PADI2, PADI3 | MCHR1 4874/4885PADI4 1/4885PADI2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.