Sugi Predict

Sugi Predict / Compounds / SCHEMBL10067161

SCHEMBL10067161

SCHEMBL10067161

c1ccc(-c2ccc3cccnc3n2)nc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 6/20 0.59
▸ LMNA P02545 4/20 0.59
▸ TP53 P04637 4/20 0.59
▸ CCR1 P32246 3/20 0.59
▸ CCR5 P51681 3/20 0.59
▸ CCR8 P51685 3/20 0.59
▸ SMN1; SMN2 Q16637 3/20 0.59
▸ ALOX15 P16050 2/20 0.59
▸ HTT P42858 2/20 0.59
▸ L3MBTL1 Q9Y468 2/20 0.59
▸ TDP1 Q9NUW8 2/20 0.59
▸ ALPL P05186 1/20 0.59
▸ HSP90AA1 P07900 1/20 0.59
▸ ALPI P09923 1/20 0.59
▸ ALPG P10696 1/20 0.59
▸ MAPK1 P28482 1/20 0.59
▸ METAP1 P53582 3/20 0.56
▸ CYP1A2 P05177 1/20 0.56
▸ POLB P06746 1/20 0.56
▸ BLM P54132 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31275638 0.90 KDM4E (0.67) KDM4ELMNATP53CCR1CCR5
SCHEMBL1089189 0.89 ALDH1A1 (0.55) KDM4ELMNATP53CCR1CCR5
SCHEMBL29707169 0.88 KDM4E (0.52) KDM4ELMNATP53CCR1CCR5
SCHEMBL21365377 0.88 KDM4E (0.52) KDM4ELMNATP53CCR1CCR5
Dipyridyl SCHEMBL9872270 0.87 KDM4E (0.67) KDM4ELMNATP53CCR1CCR5
SCHEMBL23418270 0.82 ALDH1A1 (0.54) KDM4ELMNATP53SMN1; SMN2ALOX15
SCHEMBL29484745 0.82 ALDH1A1 (0.54) KDM4ELMNATP53SMN1; SMN2ALOX15
SCHEMBL21841064 0.82 AURKA (0.47) KDM4ELMNATP53CCR1CCR5
SCHEMBL5309600 0.80 KMT2A (0.50) KDM4ELMNATP53CCR1CCR5
SCHEMBL11992064 0.79 CCR1 (0.57) KDM4ELMNACCR1CCR8ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114621261-B Based on [ Cu ] 4I Cl 4 ]Process for preparing polypyridyl complexes 安阳师范学院 2023-08-15 — — CN claimed
CN-114621261-A Based on [ Cu ]4ICl4]Process for preparing polypyridyl complexes 安阳师范学院 2022-06-14 — — CN claimed
CN-117202987-A Microcapsules based on acetoacetyl polymers 弗门尼舍有限公司 2023-12-08 — — CN disclosed
CN-117098598-A Crosslinked core-shell microcapsules 弗门尼舍有限公司 2023-11-21 — — CN disclosed
CN-114621261-B Based on [ Cu ] 4I Cl 4 ]Process for preparing polypyridyl complexes 安阳师范学院 2023-08-15 — — CN disclosed
CN-114621261-B Based on [ Cu ] 4I Cl 4 ]Process for preparing polypyridyl complexes 安阳师范学院 2023-08-15 — — CN disclosed
CN-114621261-A Based on [ Cu ]4ICl4]Process for preparing polypyridyl complexes 安阳师范学院 2022-06-14 — — CN disclosed
CN-114621261-A Based on [ Cu ]4ICl4]Process for preparing polypyridyl complexes 安阳师范学院 2022-06-14 — — CN disclosed
WO-2021224809-A1 PROLINE HYDROXYLASE INHIBITORS FOR USE IN THE SKELETAL MUSCLE REGENERATION POLICLINICO SAN DONATO S.P.A. - ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO (IT) 2021-11-11 — — WO disclosed
US-10781226-B2 Photoactivatable cancer prodrug TEXAS STATE UNIVERSITY (US) 2020-09-22 — — US disclosed
US-20200239503-A1 PHOTOACTIVATABLE CANCER PRODRUG TEXAS STATE UNIVERSITY 2020-07-30 — — US disclosed
US-9273002-B2 Benzo[k]fluoranthene derivative and organic electroluminescence device containing the same IDEMITSU KOSAN CO., LTD. (JP) 2016-03-01 — — US disclosed
US-9255118-B2 Light induced drug release UNIVERSITEIT LEIDEN (NL) 2016-02-09 — — US disclosed
CN-104193628-B Amino arone compound used as medical intermediate and synthetic method thereof LI SHULAN (CN) 2015-11-18 — — CN disclosed
CN-104193628-A Amino arone compound used as medical intermediate and synthetic method thereof ZHUANG WEIPING 2014-12-10 — — CN disclosed
US-20140148425-A1 LIGHT INDUCED DRUG RELEASE UNIVERSITEIT LEIDEN (NL) 2014-05-29 — — US disclosed
EP-2626346-A1 BENZO[K]FLUORANTHENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE ELEMENT CONTAINING SAME Idemitsu Kosan Co., Ltd. (JP) 2013-08-14 — — EP disclosed
US-20120211743-A1 BENZO[k]FLUORANTHENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE DEVICE CONTAINING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2012-08-23 — — US disclosed
US-20120211743-A1 BENZO[k]FLUORANTHENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE DEVICE CONTAINING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2012-08-23 — — US disclosed
WO-2012052821-A1 LIGHT INDUCED DRUG RELEASE UNIVERSITEIT LEIDEN (NL) 2012-04-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140148425-A1 LIGHT INDUCED DRUG RELEASE IK, MC1R, SUCNR1 KDM4E 1551/4885LMNA 3061/4885TP53 3127/4885
US-10781226-B2 Photoactivatable cancer prodrug UGT1A7, DCPS, PPOX KDM4E 2483/4885LMNA 2803/4885TP53 75/4885
US-20120211743-A1 BENZO[k]FLUORANTHENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE DEVICE CONTAINING THE SAME KCNJ2, KCNE1, KCNK2 KDM4E 764/4885LMNA 1575/4885TP53 2879/4885
US-20200239503-A1 PHOTOACTIVATABLE CANCER PRODRUG UGT1A7, DCPS, PPOX KDM4E 2483/4885LMNA 2803/4885TP53 75/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.