Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 8/20 | 0.69 |
| ▸ | CSNK2B | P67870 | 8/20 | 0.69 |
| ▸ | CSNK2A1 | P68400 | 8/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.65 |
| ▸ | TERT | O14746 | 1/20 | 0.65 |
| ▸ | POLH | Q9Y253 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | FYN | P06241 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8934505 | 0.92 | CYP1A1 (0.69) | CSNK2A2CSNK2BCSNK2A1KDM4ECYP2C19 | |
| SCHEMBL8934614 | 0.86 | KDM4E (0.74) | CSNK2A2CSNK2BCSNK2A1KDM4ECYP2C19 | |
| SCHEMBL7603180 | 0.85 | FYN (0.73) | CSNK2A2CSNK2BCSNK2A1KDM4ECYP2C19 | |
| SCHEMBL2218499 | 0.84 | POLH (0.75) | CSNK2A2CSNK2BCSNK2A1KDM4ECYP2C19 | |
| SCHEMBL4160578 | 0.84 | CSNK2A2 (0.81) | CSNK2A2CSNK2BCSNK2A1KDM4ECYP2C19 | |
| SCHEMBL10037938 | 0.82 | CSNK2A2 (0.74) | CSNK2A2CSNK2BCSNK2A1KDM4ECYP2C19 | |
| SCHEMBL31552889 | 0.82 | ALDH1A1 (0.76) | CSNK2A2CSNK2BCSNK2A1KDM4ECYP2C19 | |
| SCHEMBL7127301 | 0.82 | CYP1A1 (0.86) | — | |
| SCHEMBL14697033 | 0.82 | CSNK2A2 (1.00) | CSNK2A2CSNK2BCSNK2A1KDM4ECYP2C19 | |
| SCHEMBL6796626 | 0.82 | TERT (0.77) | CSNK2A2CSNK2BCSNK2A1TERT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466195-B2 | Methods and compositions for treating complications of diabetes and vascular diseases using flavones | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2013-06-18 | — | — | US | disclosed |
| US-20120016016-A1 | METHODS AND COMPOSITIONS FOR TREATING COMPLICATIONS OF DIABETES AND VASCULAR DISEASES USING FLAVONES | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2012-01-19 | — | — | US | disclosed |
| WO-2010105253-A2 | METHODS AND COMPOSITIONS FOR TREATING COMPLICATIONS OF DIABETES AND VASCULAR DISEASES USING FLAVONES | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2010-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120016016-A1 | METHODS AND COMPOSITIONS FOR TREATING COMPLICATIONS OF DIABETES AND VASCULAR DISEASES USING FLAVONES | SLC5A2, LIPG, TIE1 | CSNK2A2 4451/4885CSNK2B 4604/4885CSNK2A1 4464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.