Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | HK1 | P19367 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | G6PD | P11413 | 1/20 | 0.38 |
| ▸ | IDE | P14735 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31121547 | 0.90 | PKM (0.47) | PARGPKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL55616 | 0.90 | PKM (0.47) | PARGPKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2265043 | 0.90 | PKM (0.47) | PARGPKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2264974 | 0.86 | PKM (0.48) | PARGPKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL17948135 | 0.86 | PKM (0.53) | PARGPKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7125518 | 0.84 | PARG (0.59) | PARGPKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL30007977 | 0.84 | KMT2A (0.56) | PARGPKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL919135 | 0.84 | KMT2A (0.56) | PARGPKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL21104695 | 0.82 | SMN1; SMN2 (0.54) | PARGPKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL25171455 | 0.80 | TDP2 (0.56) | PARGPKMSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129519-B2 | Derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine and uses thereof | ALLERGAN SALES, LLC | 2012-03-06 | — | — | US | disclosed |