Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | S100A4 | P26447 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | HK1 | P19367 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PARG | Q86W56 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL55616 | 0.95 | PKM (0.47) | PKMALDH1A1GAAAPEX1MEN1 | |
| SCHEMBL31121547 | 0.95 | PKM (0.47) | PKMALDH1A1GAAAPEX1MEN1 | |
| SCHEMBL2265043 | 0.95 | PKM (0.47) | PKMALDH1A1GAAAPEX1MEN1 | |
| SCHEMBL21104695 | 0.92 | SMN1; SMN2 (0.54) | PKMALDH1A1S100A4MEN1KMT2A | |
| SCHEMBL30007977 | 0.89 | KMT2A (0.56) | PKMALDH1A1S100A4MEN1KMT2A | |
| SCHEMBL919135 | 0.89 | KMT2A (0.56) | PKMALDH1A1S100A4MEN1KMT2A | |
| SCHEMBL10070529 | 0.86 | PARG (0.44) | PKMALDH1A1MEN1KMT2APOLB | |
| SCHEMBL25171455 | 0.85 | TDP2 (0.56) | PKMALDH1A1GAAAPEX1S100A4 | |
| Dioxane SCHEMBL28440846 | 0.80 | PARG (0.49) | PKMALDH1A1S100A4MEN1KMT2A | |
| SCHEMBL19682469 | 0.79 | PPOX (0.53) | ALDH1A1HSD17B10TDP1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10731040-B2 | Crosslinked phenolic compound, method of forming, and polymer composition containing the same | THE UNIVERSITY OF MASSACHUSETTS (US) | 2020-08-04 | — | — | US | claimed |
| US-20180016445-A1 | CROSSLINKED PHENOLIC COMPOUND, METHOD OF FORMING, AND POLYMER COMPOSITION CONTAINING THE SAME | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY | 2018-01-18 | — | — | US | claimed |
| US-11932599-B2 | Ferroptosis inducing compound, compositions comprising the same, and methods of inducing ferroptosis | UNIVERSITY OF MASSACHUSETTS (US) | 2024-03-19 | — | — | US | disclosed |
| US-20220324798-A1 | FERROPTOSIS INDUCING COMPOUND, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF INDUCING FERROPTOSIS | UNIVERSITY OF MASSACHUSETTS | 2022-10-13 | — | — | US | disclosed |
| US-10947188-B2 | Small molecule ferroptosis inducers | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-03-16 | — | — | US | disclosed |
| US-10947188-B2 | Small molecule ferroptosis inducers | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-03-16 | — | — | US | disclosed |
| US-10731040-B2 | Crosslinked phenolic compound, method of forming, and polymer composition containing the same | THE UNIVERSITY OF MASSACHUSETTS (US) | 2020-08-04 | — | — | US | disclosed |
| US-20190315681-A1 | SMALL MOLECULE FERROPTOSIS INDUCERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2019-10-17 | — | — | US | disclosed |
| US-20190315681-A1 | SMALL MOLECULE FERROPTOSIS INDUCERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2019-10-17 | — | — | US | disclosed |
| WO-2018118711-A1 | SMALL MOLECULE FERROPTOSIS INDUCERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-06-28 | — | — | WO | disclosed |
| US-20180016445-A1 | CROSSLINKED PHENOLIC COMPOUND, METHOD OF FORMING, AND POLYMER COMPOSITION CONTAINING THE SAME | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY | 2018-01-18 | — | — | US | disclosed |
| US-7211695-B2 | β2-adrenergic receptor agonists | THERAVANCE, INC. (US) | 2007-05-01 | — | — | US | disclosed |
| US-7179794-B2 | Multivalent macrolide antibiotics | THERAVANCE, INC. (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179794-B2 | Multivalent macrolide antibiotics | THERAVANCE, INC. (US) | 2007-02-20 | — | — | US | disclosed |
| US-7173039-B2 | Protein kinase inhibitors | THERAVANCE, INC. (US) | 2007-02-06 | — | — | US | disclosed |
| US-7173039-B2 | Protein kinase inhibitors | THERAVANCE, INC. (US) | 2007-02-06 | — | — | US | disclosed |
| US-6693136-B1 | DISULFONAMIDE DERIVATIVES; PAIN, URINARY INCONTINENCE, BLADDER OVERACTIVITY | ABBOTT LABORATORIES | 2004-02-17 | — | — | US | disclosed |
| US-20040019042-A1 | FLUORENES AND ANTHRACENES THAT INHIBIT P2X3 AND P2X2/3 CONTAINING RECEPTORS | ABBVIE INC. | 2004-01-29 | — | — | US | disclosed |
| US-4997737-A | Contain sulfonyl group | EASTMAN KODAK COMPANY (US) | 1991-03-05 | — | — | US | disclosed |
| US-4948911-A | ELECTRON-TRANSPORT AGENTS | EASTMAN KODAK COMPANY (US) | 1990-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11932599-B2 | Ferroptosis inducing compound, compositions comprising the same, and methods of inducing ferroptosis | AIFM2, AIFM1, FECH | PKM 2106/4885ALDH1A1 2428/4885GAA 4392/4885 |
| US-10947188-B2 | Small molecule ferroptosis inducers | GPX4, AIFM2, GPX1 | PKM 1696/4885ALDH1A1 845/4885GAA 2121/4885 |
| US-20040019042-A1 | FLUORENES AND ANTHRACENES THAT INHIBIT P2X3 AND P2X2/3 CONTAINING RECEPTORS | P2RX3, P2RX1, P2RX2 | PKM 2501/4885ALDH1A1 323/4885GAA 3870/4885 |
| US-20190315681-A1 | SMALL MOLECULE FERROPTOSIS INDUCERS | GPX4, AIFM2, GPX1 | PKM 1696/4885ALDH1A1 845/4885GAA 2121/4885 |
| US-20220324798-A1 | FERROPTOSIS INDUCING COMPOUND, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF INDUCING FERROPTOSIS | AIFM2, AIFM1, FECH | PKM 2106/4885ALDH1A1 2428/4885GAA 4392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.