Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30414275 | 0.80 | USP2 (0.35) | KDM4EMAPTTHRBUSP2SMN1; SMN2 | |
| SCHEMBL27651390 | 0.80 | USP2 (0.35) | KDM4EMAPTTHRBUSP2SMN1; SMN2 | |
| SCHEMBL4511304 | 0.77 | MAPK1 (0.46) | KDM4EMAPTTHRBUSP2SMN1; SMN2 | |
| SCHEMBL513188 | 0.77 | USP2 (0.43) | KDM4EMAPTTHRBUSP2SMN1; SMN2 | |
| SCHEMBL4388001 | 0.76 | PLA2G10 (0.43) | KDM4EPARP1DDB1CRBNSCN9A | |
| SCHEMBL7495565 | 0.76 | LMNA (0.47) | KDM4EMAPTTHRBUSP2SMN1; SMN2 | |
| SCHEMBL20352051 | 0.75 | NR1H2 (0.43) | KDM4EMAPTTHRBUSP2SMN1; SMN2 | |
| SCHEMBL26091030 | 0.75 | FPR2 (0.42) | KDM4EMAPTTHRBUSP2SMN1; SMN2 | |
| SCHEMBL8264195 | 0.74 | NPSR1 (0.33) | — | |
| SCHEMBL16903622 | 0.74 | MAPK1 (0.50) | KDM4EMAPTTHRBUSP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 106 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4689155-A1 | USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS | Astrazeneca AB (SE) | 2026-02-11 | — | — | EP | disclosed |
| EP-4630410-A1 | POLQ INHIBITORS | Astrazeneca AB (SE) | 2025-10-15 | — | — | EP | disclosed |
| US-12414954-B2 | POLQ inhibitors | ASTRAZENECA AB (SE) | 2025-09-16 | — | — | US | disclosed |
| WO-2025149545-A1 | HETEROARYLPHENYL ETHER DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2025-07-17 | — | — | WO | disclosed |
| US-20250195530-A1 | POLQ INHIBITORS | ASTRAZENECA AB (SE) | 2025-06-19 | — | — | US | disclosed |
| US-20250177362-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. | 2025-06-05 | — | — | US | disclosed |
| WO-2025106482-A1 | COMPOUNDS AND COMPOSITIONS AS SMARCA2/4 DEGRADERS AND USES THEREOF | ONCOPIA THERAPEUTICS, INC. D/B/A SK LIFE SCIENCE LABS (US) | 2025-05-22 | — | — | WO | disclosed |
| US-20250049966-A1 | SMALL MOLECULE TRACER FOR IMAGING ALPHA-SYNUCLEIN AGGREGATES | FUDAN UNIVERSITY (CN) | 2025-02-13 | — | — | US | disclosed |
| CN-119390697-A | Heterocyclic compound, preparation method and application thereof | 西安医学院 | 2025-02-07 | — | — | CN | disclosed |
| CN-119343343-A | Heterocyclic GLP-1 agonists | 加舒布鲁姆生物公司 | 2025-01-21 | — | — | CN | disclosed |
| EP-1470114-A1 | PEPTIDE NUCLEIC ACID OLIGOMERS FROM 1-BENZENESULFONYL-3-AMINO ACID SIDE CHAIN-4-(2-NUCLEOBASE(ACETYL))-PIPERAZIN-2-ONES | Panagene, Inc. (KR) | 2004-10-27 | — | — | EP | disclosed |
| US-20030225252-A1 | PNA monomer and precursor | PANAGENE, INC. (KR) | 2003-12-04 | — | — | US | disclosed |
| WO-2003091231-A1 | PNA MONOMER AND PRECURSOR | PANAGENE, INC. (US) | 2003-11-06 | — | — | WO | disclosed |
| US-20030195332-A1 | PNA monomer and precursor | PANAGENE, INC. (KR) | 2003-10-16 | — | — | US | disclosed |
| US-6632818-B2 | Piperazine-containing macrocyclic compounds | MERCK & CO., INC. | 2003-10-14 | — | — | US | disclosed |
| WO-2003062212-A1 | PEPTIDE NUCLEIC ACID OLIGOMERS FROM 1-BENZENESULFONYL-3-AMINO ACID SIDE CHAIN-4-(2-NUCLEOBASE(ACETYL))-PIPERAZIN-2-ONES | PANAGENE, INC. (US) | 2003-07-31 | — | — | WO | disclosed |
| US-20030134860-A1 | Inhibitors of prenyl-protein transferase | MERCK SHARP & DOHME CORP. | 2003-07-17 | — | — | US | disclosed |
| WO-2001051494-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-07-19 | — | — | WO | disclosed |
| EP-0783500-B1 | AMINOHETEROCYCLIC DERIVATIVES AS ANTITHROMBOTIC OR ANTICOAGULANT AGENTS | ZENECA LTD (GB) | 1998-07-22 | — | — | EP | disclosed |
| EP-0202048-B1 | CARBAPENEM DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANKYO COMPANY LIMITED (JP) | 1991-10-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195332-A1 | PNA monomer and precursor | RNGTT, NGLY1, NCL | KDM4E 4788/4885MAPT 4430/4885THRB 1465/4885 |
| US-20030225252-A1 | PNA monomer and precursor | PNISR, RNGTT, NCL | KDM4E 4848/4885MAPT 4396/4885THRB 717/4885 |
| US-12414954-B2 | POLQ inhibitors | POLQ, POLG, POLB | KDM4E 2215/4885MAPT 1924/4885THRB 3120/4885 |
| US-20030134860-A1 | Inhibitors of prenyl-protein transferase | FNTA, FNTB, RCE1 | KDM4E 1761/4885MAPT 4293/4885THRB 2795/4885 |
| US-20250177362-A1 | HETEROCYCLIC GLP-1 AGONISTS | GLP1R, GIPR, IAPP | KDM4E 3866/4885MAPT 3395/4885THRB 159/4885 |
| US-20250195530-A1 | POLQ INHIBITORS | POLQ, POLG, POLB | KDM4E 2215/4885MAPT 1924/4885THRB 3120/4885 |
| US-20250049966-A1 | SMALL MOLECULE TRACER FOR IMAGING ALPHA-SYNUCLEIN AGGREGATES | SNCA, PARK7, GDI1 | KDM4E 3559/4885MAPT 18/4885THRB 3461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.